??????, ????????? ????????? ??? ???????? ?????? ?????????

???????? ???? ??? ????? ??????, HMB-Ca ???????????? ???? ????? ????????? (????????????) ???????? ??? ????????? ????? ????? ?????????? ??????????? ???? ?????? ?? 65 ????? ???? ????? ?????? ????????? ???????? 3 ????? HMB-Ca ??????? ????? ????, ?????? ???????? ??????????? ???? ????? ??, 12 ?????? ???, ????-??????????? ??? ???? ?? 1.2 ???? ?????? ????, ????? ????? 14% ?????? ???? ??? ????????? ??? ??????? ??? 23% 34 ? ????? ????? ?? ???? ??????????? ????? ??????:

?

? mTOR ???? ?????????? ?: ???? ??????? ?????????? ?????? 38% ?????? ????????

? ????????? ?????????? ??????? ??????? ?: ???? ?????? ???????????? (???? MuRF1) ?????? 41% ????? ????????

? ???????? ???????? ?????????? ??? ?: ????-????????????? ???????? IL-6 ?? ?????? 29% ????? ??? ???????????? ?????? ????? ??? ?

???????? ?????? ????????, ??????? D3 ?? ???? HMB-Ca ?? ????????? ?????? ????????? ?????? ??? 17% ???????? ??? ????? ????????-????????? ????????? ???????? (SASP) ??????? 34% ????????? ??????? ???????? ??????? ??????? ??????? ??????? ???????? ????? ??????? ??? ???? ???? HMB-Ca ?? ???????? ????????? ????????? ???????? ???????? ???? ??? ???????? ???? ???????? ??????????? ?????? 19% ?????? ???????

?

?. ??????????? ?????? ??????? ????????? ???????

???? ??? ???????????? ????????? ????? ????????? HMB-Ca ???? ???????????? ?????? ?????? ?????? ???????? ?????:

?

? ????????? ????????????? ??????????? ?: ??????????? ?????????? ???????? ??????? ????????????? ??? ?????-? ?????? ????????? ???? ? ????? HMB-Ca ??????? ????? ???? ?????? ?? ????? ??% ????? ???? ??? ?????????? ???????? ??% ?????? ?????

? ????? ?????? ??????? ?: ?????? ???????? ????? ??????? ??% HMB-Ca ???????? ???????? ?????? ????????? ??????? ???, ???? ????????? ???? ?-? ??? ?????? ??? ??? ??? ??????? ?????????? ??? ??% ??? ?????

? ??????????? ????????? ??????? ? : COPD ??????? ???????? HMB-Ca ??? ??????????? ???????? ????????? ???????? ???????, ? ??? ???, ? ??????? ?????? ?????? ?? ????? ?????? ???????, ????????????? ????? ????? ??% ?????? ????????

??????? ????? ? ???? ??????? (?????) ????? ???????? ?????????? ???????? ???? HMB-Ca ?? "???? ????" ?????? ??????? ????? ??? ?????? ????????? ??????????? ????? ???? ???? ?? ????? ?????? ??????????? ????? ??% ????? ?????? ??? ??????????????? ?????????? ?????????? ??% ???????? ???????

?

?. ???????? ??? ????????????? ??????

???????????? ????? ??????????? HMB-Ca-?? ???? ?????????? ???????? ??????:

?

? ??????? ??????????? ? : ???? 2 ?????????? ??????? 12 ?????? ??? HMB-Ca ????? ??????? ??????? ????????, HOMA-IR ???? 23% ????? ??????? ??? ???????? ?????? ??????? ????? 37% ?????? ????????

? ????? ??????? ???????? ?: AMPK ?? ??????? ???? ???????, ?????? ????????????????? ?????? ??% ????? ???? ??? ????????????????? ?????? ??% ?????? ?????

? ???????? ?????????????? ?????????? ?: ????-???? ?????? ??????? ?????? ??% ?????? ??????? ??? ???????? ???? ????? ????? ??% ????? ?????? ? ???????????/???????????? ???????? ?????????? ?????

?????????????? ?????? ????? ????? ?????????, ??????????? ???? HMB-Ca ?? ????? ????????? ?????? ????? ?????????? ????? 1.2 ????? ????? ??? ??? ALT ???????????? ??? 68% ?57 ? ?????? ???? ???????? ????????? ???????? ????????? ??? ??? ???? RCT ???????? 24 ???????? ??????????? ??? ??????????????? ?????? ????? ????? (ASCVD) 19% ????? ?????? ???????

?

?. ????? ??????? ????????? ????? ???????

HMB-Ca-?? ??? ?????? ??? ????? ??????? ????????? ????????? ??????? ??????? ????????? ????:

?

???????????-????? ????????? ?: ??????? ?????????????? ??????? ????????, ????????????? 3 ??? ??? 6 ????? HMB-Ca/???? ??????? ????? ???? ??????????? ??????? ???? ????? ???????????? ??? 2.3 ??? ?????? ???? ???? ??? ????????? ????? ??????? 2.5 ??? ???? ???? ?

? ??????????? ???????? ?????? ??????? ?: ???? ??? ?????? ??????????? ??????? HMB-Ca ???????? ????? ???????? ??????? ????????????? ??????? 41% ???????? ??? ??????? ?????? 57% ????? ??????

? ???????? ?????? ??????? ?: ???? ???? ?????? HMB-Ca (50mg/kg/d) ?? ??????? ?????? ??? ?????? 24% ??? ?????????????? ????? 19% ?????? ????

????? ?????? ????????? ????? ????? ??????? ????????? ???? ??????? ??????? ?????????? ????????? HMB-Ca ??????????? ????? ??? ???????? ??? ?????? ????? ??? ?????????? ????????? ??? ?????? ????? ?8 ?? 6?? ?????? ???????? ?? ??????? ??????? ?????? ?????? ?????? HMB-Ca ?????-????? ??????????????? ????????? ???????? ?????? ??? 91% ? ?????? ???? ???? ??? ?????? ?????? ??????? ???????? ????? ±7% ? ??????? ???? ?????

?

?. ??????? ????????? ????? ??????????

?????????? ??????? ?????? ????????? ?????, ????????? ????????? HMB-Ca-?? ??????? ??????? ???????? ?????:

?

? ??????? ???? ????????? ? : ?????????? ????? ???????? ??????? ????????, HMB-Ca ??? ???????? ????????? ????????? ???????? 6 ??? ??? ??????? ???? ??????? ????-??????? ?????? 17% ??? ADL ????? 23% ?????? ????

? ?????????? ???????? ?????????? ?: ????????????? ?????????? ????????? ?????????? ???, HMB-Ca ???????, ????????????? ??????????? ?????? 58% ?????, 3-4 ?????? ??? ????????? ???? ??? ?

? ?????? ???????? ??????? ? : ??????????? ?????? ??????? ????????? ???????? ? ????? HMB-Ca ????? ???? ????????????????? ???? ????? ??% ??? ?????? ????? ??????? ??? ??% ??????

???????? ?????? ???????? ????????, HMB-Ca ????????????? ??????? ?????????????? ?????????? ??? ??? ?????????? ?????? ??% ??? ???????? ???? ?????? ??????? ??% ????????? ??????? ????????????? ?? ???????? ??????? ??????? ??? ?? ????-???????? ???????? ? ?????? ??? HMB-Ca ??????????? ????????? ???? ???? ????? ?????? ????? ??% ????? ???? ?????

?

?.????????? ??????: ???????????? ?????? ??? ???????

HMB-Ca-?? ??????????? ??????? ???? ??????????? ????????? ???? ????:

?

? ?????? ???????? ??????? ?: ????????? ?????????????? HMB-Ca ?? ??????????? ????????? ???? ???????? ??? 3.7 ??? ?????? ??? ??? ??????? ???? 72 ????? ??????? ??????? ??? ?

? ????????? ???????? ????????? ? : HMB-Ca ?? ??? 62% ????? ???????, HMB-CA ?? ????????? 99.9% ???????????????? ????? ?????????????? ??????? ?

? ??????? ?????? ????????? ?: ??????? ?????? ?????????? HMB-Ca ??????? ?????-????? ?????, ??????-???? EMG ? ??????? ????? ??? ?????????? ????????? ????

??? ????????? ??????? HMB ???????? ?? ?????????? ???? ????? ??? ??? CRISPR-Cas9-?????????? HMB ?????????? ???????? ???????????? ??? ???? ????? ????? ???? ???? 29% ????????? ?????? ???? ??????? ????? HMB-Ca ????????? ????????? ????????? ????????? ???????? ?????? ????? ??? ?? ??? ???????? ?????????? ??? ?????? ??????? 2.8 ??? ?????

????????? ??? ????????? ????????????

???? HMB-Ca-?? ????????? ??????? ???????? ??????, ???? ??? ??? ???? ????????:

?

? ??? ?????????? ?: ???????????? ????????? ???? ???????? ? ????? ??????? ?? ???? ??????? ?????? ???, ???????? ?????? ?????????????????????? ????????? ???? ??? ???? ?

? ?????? ???????????? ?: ??? ??????? ???? ?-? ??? ????? ???? ??????? ?????? ??? ??? ?????? ???????? ????? ?????????? ????????? ????????? ???? ???? ???? ?

? contraindication ? : ???? ???????? ?????????????????? ????? ???? mTOR ??????? ???????????? ?????? ??? ???? ?

?????????????? ??????? ?? ???????? ????????? (ISSN) ?? ?????????? ?????? ?????? ?? 2-3 ?????? ??? HMB-Ca ?? ??????? ????????? ????? ?????? ??? ??? ???????????? ??? 1-2 ?????/???? ????????? ??? ???? ????? ????????? ????????? ?????? ???????? ???? ????, HMB-Ca ???? ???????? ??????? ???? ???? ???-?????? ?????? ???????? ??????? ?????? ????? ??? ?? ????? ???? ???? ???????? ????? ?