?. ??????? ??????? ???????? ??????????

??????? ? ???-???? ??????????? ?????? ??????? ????? ???? ???????? ?????? ???????? ????? ???:

?

?mTOR ???????? ???????????? ?: ???????? S6 ?????? ??????????? ???? 38% ??????, ???????? ???? ???? ??? ???????? ??? ??????? ?????????? ?????? ? ???????????

? ubiquitination ?? ???????? ?????? ?: E3 ubiquitin ligase MuRF1 ?? ?????? 41% ????? ?????, ??? ???? ???????? ????? ??????????? ???????????? ??????? ????? ?

? ????????? ?????????????? ?: ???????? ?????????? ????? ???? ???????? ????? ??? ???? LC3-II/LC3-I ?????? 1:1.5 ? ????????? ?????

?????????, ??? ?????? ??????? ????????? ???????

?????-?????? ??????????? ??????? HMB ????? ??????????? ???????:

?

? ??????? ??? ???????????? ?: ???????????????????? ?????? 27% ?????? ???, ???? ??????? ????????? ????? ???????? ?????? ????? ??? ?

? ??????????? ???? ?????????? ?: ???????????????? ??????????????? ????????? ??????? ?????????? ????? ???? ???? ??? ??????????? ????????? ????? 63% ????? ?

? ?????????? ??????? ??????? ? : ??????? Nrf2 ??, ???????????? ????????? (SOD) ?? ????????? 41% ?????? ????????

III. ??????? ???????? ???????????? ????

1. ???? ??????? ??????? ???????

????? ??????????? ???????? ? ????? HMB ??????????? ????? ???? ??? ?????????? ?????? (CK) ??% ??? ???? ??? ???? ?????? ??????? ??% ??? ?????

?? ????? ??????????? ?????????? ??, ???? ?????????? Z-???? ??????? ???? ??% ????? ??????? ??? ???????????????? ???????? ??????? ??% ????? ???????

2. ???????? ?????????? ????????????

???????? ?????????? ????? ?????????? ?????? ??% ????? ??? ?????? ???????????? ???? ??% ?????? ????????

?-???????? ??????? ???? VO2max ?.?% ?????? ????? ??? ?????????? ???????? ??% ?????? ??????

?. ??????????? ?????????? ???????

?. ???????? ?????????? ??????????? ???????? ??? ???????

?? ??? ??? HMB ????? ?????? ??????? ????????, ???????????? ????? ??????? ?.? ???? ???? ??? ???? ?????? ??? ??-???? ???????????? ???????? ??? ??% ?????? ????

?????? ????? ??????? ????????, ??????? ???????? ??? ??% ?? ??? ??? ???? ????????? ???? ? ??? ?? ????

?. ???????????? ????????????? ?????????

?? ???????? ??????????? ??, ?? ????? ???? ????? ????????? ???????? ??? ?.?? ??/??????? ?????? ??????? ??? ???? ??????? ????? ??% ??????

???????? ??????????????? ????? ??????????? ??% ????? ??? ???? II ???? ?????? ??????? ??% ?????? ???? ?????

?. ?????????? ??????????? ???????

?????? ???????? ???????

???????? ????????????? ????????? ????? ?????? ????? ?.? ??? ?????? ????? ??? ?????? ??????? ???????? ??? ???

??????? ?????????????? ??????? EMG ???????????? ?????????? ????? ??? ??? ??????? ???????? 15 ???????? ?????? ??? ?

? ????????? ????????? ???????? ??????

??????????? ??????? ??? ?.? ?????/?????? ?????? ??? ??????? ??? ?????? ??? ??% ????? ??? ????????

CRISPR ???????? ????????? ???? ???????? ??% ?????????? ???, ????-??????????? ????????? ?????? ??? ?

?.?????????? ????????????

? ????? ????????? ? : ??????? ???????? ????? LD50 > 5000mg/kg, ???? ?-??????? ?

? ???????????? ??????? ? : ?? ??? ??????????? ???? ???? ??????????? ????????? ????????? ?????, ??? ?????????????????????? ????????? ???? ???

? ??? ????????????? ?: ???????????? ?????????? ?????? ???????? 3 ?????/??? ??????? ??????? ?????? ???, ?????????? ??? ???? ???? ?????? ??? ??? ?

?????? ????????? ???????????

? ?????????? ?????????? ?: ???? ????? ????? ????? ????????? ??????????? ??? HMB-?? ?????? ??????? ?

? ???????????? ???????????? ????????????? ?????????? ?: ???????? ??????????/???????????? ???????? ??? HMB ??????? ?????????? ??????? ???????? ?