?????, ????????? ????????? ??? ???????? ?????? ?????????

????????? ????? ?????????? ?????, HMB-Ca ? ?????? ?????? ??? ????????? (???????????) ?? ?????? ??? ????????? ????? ????? ?????????? ??. ???????? ???? ??????? ?? ?? 65 ?????? ??? ?????? ????? ???? ????? 3 ????? HMB-Ca ???? ????? ??, ????? ???????? ????? ????, 12 ???????? ???, ?????? ?????? ?????? ??????? 1.2 ?????? ????? ???, ??? ???????? 14%?? ????? ???, ??? ?????? ?????? ?????? ?? 23% ???? ????????.34. ???? ?????? ?????? ????????? ????? ??:

?

? mTOR ???????? ?????????: ?????? ??????? ???????? ?????????????? 38% ?????.

? ??????? ??????????? ??????? ?????? ?: ?????? ????? ???????? (??? ?? MuRF1) ?? ????????????? 41% ????? ???.

? ????? ???????? ????????? ??? ?? ?: ????-???????????? ?????? IL-6 ?? ?????? 29% ????? ?? ??? ??????? ???????? ?????? ??? ?? ?

???????? ?????? ??????????, ??????? D3 ???? HMB-Ca ?? ????????? ??????? ??????? ???????? ?? 17% ???? ????? ??? ??? ?????-??????? ????????? ???????? (SASP) ??????????? 34% ????? ?????. ???????? ????? ????????? ?????? ?????? ?????? ???????? ????? ?????? ???? ???? ???? HMB-Ca ?? ?????? II ???????? ?????? ????? ?????? ??, ??? ????????? ???? ?????????? ????? ?????????? 19% ?????? ??????? ??.

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2. ???????? ???? ???? ?????????? ???????

????? ??? ??????? ???? ?????? ????????? HMB-Ca ?? ????? ???? ????? ????? ???? ?????? ??:

?

? ?????? ?????????? ?????????? ? : ?????????? ?????? ?????? ????????? ?????-3 ???? ???? ???? 3 ????? HMB-Ca ??? ???????????? ??? ???? ?????? ?????? ?????? 62% ????? ?? ??? ?? ??? ?????????? ????????? 38% ??? ??? ??.

? ???? ????? ?????? ? : ?????? ????? ?? ???? ????? 30% ?????? HMB-Ca ?????? ?????? ???? ????????? ????? ??? ??, ?? ????????? ??? 5-7 ???? ??? ??? ??, ??? ??????? ????????? ?? 41% ??? ??? ??.

? ????? ???????? ????????? ? : COPD ????????? HMB-Ca ??? ?????????? ????? ?????? ??????? ?????, 6 ????? ???, 6-???????? ???????? ???? 82 ???? ??????, ????? ????????? ???????? 21% ?? ????? ???.

???? ?????? ??????? ????????? ???????????? ?????? ???? HMB-Ca ?? "???? ???" ????? ?????? ??? ??, ??? ?????? III ?? ???????? ???? ??????? ?? ?? ???? ?????? ????? ???????? 28% ?????? ??? ?? ??? ???????????? ?????????? ???????????? 19% ????? ??? ??.

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?. ????????? ??? ????????????? ?????

???????????? ???????? ???????? HMB-Ca ?? ??? ??????? ????? ??????? ??? ??:

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? ?????????? ??????????? ? : ???? 2 ??????????? ????????? 12 ???????? ???? HMB-Ca ???? ???? ??????? ????, HOMA-IR ???????? 23% ????? ??? ?????????? ?????? ?????????? ???? 37% ??????.

???? ????????? ????????????: AMPK ??????? ?????? ?????, ???? ????????????????? ?????? 29% ?????? ??? ??????????????? ???? 18% ??????.

? ?? ????????????? ????? ?: ????????????/???????????? ??????????? ?????? ???? ?????-???? ???? ???? ?????????? 42% ?? ????? ??? ??? ???????? ????? ????? ???????? 31% ?? ?????? ???.

???-?????????? ???? ???? ????? ?????????, HMB-Ca ?? ???????? ?????? ????????? ??????? ???? ?????????? ???????? 1.2 ??????? ????? ????? ??? ALT ?????????? ??? 68%?57 ???? ???????. ????????? ????????? ?????? ???????? ??????? ????? RCT ????????? 24 ?????????? ????????? ??? ?????????????????? ?????? ????? ????? (ASCVD) ??? 19% ????? ???? ?????.

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?. ??? ????? ????? ???? ????? ??????

HMB-Ca ?? ?????? ??? ????? ???????????? ???????? ???? ???????????? ????? ??? ????? ??:

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?????? ???????? ????????: ??????? ???????????????? ?????????, ???????? 3 ???? ????? 6 ????? HMB-Ca/???? ???? ?????? ???????????? ??? ????????? ?????????? ???????? ?? 2.3 ??? ??? ??? ?? ??? ??????????? ??????? ??????? 2.5 ???? ??? ?? ??? ??.

?????? ???? ???????? ?????: ???? ??? ?????? ???????????? ????????? HMB-Ca ?????? ????? ???? ?????? ?????????????? ???????? 41% ????? ??? ??? ????? ?????????? 57% ?????? ???.

? ????? ???? ???? ???? ? : ??????? ???? ????????????? HMB-Ca (50mg/kg/d) ?? ?????? ?????? ?????? 24% ??? ????????????????? ???????? 19% ?? ????? ???.

????? ????????? ?????? ????? HMB-Ca ?? ??? ????? ????? ???? ?????????? ????? ???? ????? ????????? ???????? ?????? ??, ??? 6 ???????? ??????????? ???? ??????? ?????? ??? ??, ????? ?????? ???? ?????????? ?????????? ??? ????????? ????????? ???? ?????????? ?????????? ?8?? ?????? ??? ??. ???????? ?????? HMB-Ca ??????????-????? ????????????? ????????? ???????? ???? ???? 91% ???? ????? ??? ?? ??? ???? ????? ?????????? ???? ???????? ±7% ???? ????? ??? ??.

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?. ?????? ???????? ?????? ???????

???????? ?????? ???? ??????? ??????, ???????? ?????? HMB-Ca ?? ????? ??? ??????? ????? ??:

?

? ???? ??? ???????? ? : ??????????? ??????? ?????????, HMB-Ca ??? ?????????? ??????? ?????????? ???????? ?????? ?????? ????? ?????-??????? ?????????? 17% ??? ADL ???????? 23% ?? ????? ???. 6 ????? ???

? ?????????? ?????? ?????? ? : ????????? ???????? ????????? ???????????? ???, HMB-Ca ????, ????????????? ??????? ?????? 58% ???, 3-4 ???????? ????? ???? ?? ???? ??? ?

? ???????? ??????? ??????????? ? : ????????????? ????? ??? ?? ?????????????? ????? 3 ????? HMB-Ca ?????? ?????????????????? ????????? ????????? 72% ??? ??????? ??????? 39% ????? ???.

???????? ??? ???? ??????? ??????????, HMB-Ca ?????????????? ???????? ?????????????? ???? ??? ??? ????????? ????????? 44% ??? ??????? ?????? ???????? ?????????? 51% ????? ?????. ??????? ???????? ?? ????????? ??????? ????? ??? ?? ?? ????-????????? ?????? 2 ???????? ????? HMB-Ca ?????????? ????????? ??? ?????? ????? ?????? ???? 37% ????? ???? ??.

?

?. ???????? ????: ????????????? ?????? ??? ??????

HMB-Ca ?? ??????????? ??????? ??? ????????? ?????? ????? ????? ??:

?

? ???? ??????? ?????? ? : ?????????? ???????? HMB-Ca ?? ?????? ?????? ?????? ???????? ???? 3.7 ??? ????? ?? ??? ??????? ??? 72 ???? ???? ????? ?? ?

? ??????? ?????????? ?????? ? : HMB-Ca ?? ????? 62% ???, HMB-CA ?? ??????? 99.9% ?????????????? ????? ?????????? ???? ?????? ?

?????? ???? ????????? ?: ????? ???? ???? ????? ???? ??????? HMB-Ca ??????? ?????????-????? ???, ????-???? EMG ? ?????? ????? ????? ?????? ???? ?????.

???? ????????? ????? ??????? HMB ????????? ??????? ??????? ????? ????? ??, ??? HMB ????????? CRISPR-Cas9-???????? ??????????????? ??????? ???? ???????? ?????? ??????? 29% ?????? ????? ???. ??????? ????? HMB-Ca ???????? ?????? ???????? ????????? ????????? ??????? ??, ??? ???? ??????????? ???????? ??? ??????? ???? 2.8 ??? ????? ??.

?????? ??? ????????? ???????????

???? HMB-Ca ?????? ????????? ???????? ??????? ??, ??? ???? ? ??????? ????? ?? ??:

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? ?????? ???????? ?: ????? ?????? ??????? ????? 5 ?????/?????? ??? ? ???? ????, ??? ????? ?????? ?????????? ????????? ?? ??? ?? ?

? ??? ???????????? ?: ???? ???? ???? 2-3 ??? ?????? ????? ??????? ??? ??, ??? ??????? ???? ????? ???????? ???? ?????????? ??????? ???? ??? ??? ?? ?

????????? ? : ???????????????? ???? ??? ???? ??? ?????? mTOR ????? ???????????? ????? ??? ??? ??.

?????????? ??????? ?? ????????? ?????????? (ISSN) ?????? ????? ?????? ?????? ??????? ?? ?? 2-3 ???????? ???? HMB-Ca ??? ???? ??????? ??????? ??? ??, ??? ?????? ?????? 1-2 ?????/???? ???? ????? ???? ??. ???????? ????????? ???????? ???? ????, HMB-Ca ?? ???? ????????? ???-??????? ?????????? ?????????? ????????? ?????? ?? ?????? ??, ??? ???? ????? ???? ??? ?? ??????? ??? ??.