Na farko, lafiyar tsofaffi da tsoffi tsoma baki

A matsayin ma?alli mai mahimmanci na leucine, HMB-Ca ya nuna ?ima na musamman a cikin rigakafi da kuma kula da ciwo na lalata tsoka (sarcopenia). Bayanan asibiti sun nuna cewa tsofaffi masu shekaru sama da 65 sun kara 3 grams na HMB-Ca kowace rana, tare da horar da matsakaicin juriya, bayan makonni 12, matsakaicin ?wayar tsoka na gabobin ya karu da 1.2kg, ?arfin kamawa ya karu da 14%, kuma matakan ha?aka saurin ha?aka ya kai 23%?34. Tsarin aikinsa ya ha?a da:

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Kunna hanyar mTOR: ha?aka ingantaccen furotin tsoka da 38%

An hana tsarin protease na ubiquitin: rage yawan bayyanar da alamun raunin tsoka (irin su MuRF1) da 41%

Yana daidaita ma'aunin kumburi: yana rage matakan pro-inflammatory factor IL-6 da 29% kuma yana inganta kumburi na kullum

A fagen rigakafin tsufa, tsarin shiga tsakani na HMB-Ca tare da bitamin D3 ya rage yawan asarar telomere da kashi 17% kuma ya rage alamun tsufa na sirrin phenotype (SASP) da kashi 34%. Cibiyar Nazarin Kiwon Lafiya ta Longevity ta ?asa a Japan tana gudanar da gwajin gwaji na asibiti na II na HMB-Ca don rage ci gaban cutar Alzheimer, kuma bayanan farko sun nuna ha?akar 19% na ?imar aikin fahimi.

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2.Gina tsarin tallafin abinci na asibiti

HMB-Ca yana fitowa a matsayin ma?alli mai mahimmanci a cikin maganin cututtuka masu tsanani da na kullum:

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Ciwon daji cachexia management: Bayan tiyata na 3 grams na HMB-Ca tare da omega-3 fatty acids a cikin marasa lafiya da ciwon daji na colorectal zai iya rage yawan asarar jiki da kashi 62% kuma ya kara yawan juriya na chemotherapy da 38%

Goyan bayan gyaran ?onawa: 30% na masu ?onawa na jiki suna amfani da shirye-shiryen abinci mai gina jiki wanda ke ?auke da HMB-Ca, lokacin warkar da rauni yana raguwa ta kwanaki 5-7, kuma an rage adadin catabolic na furotin da 41% ?

Aikace-aikacen gyaran numfashi na numfashi: Ha?in amfani da HMB-Ca da amino acid na reshe a cikin marasa lafiya na COPD, watanni 6 bayan haka, nisan tafiya na minti 6 ya karu da mita 82, ?arfin tsokar numfashi ya karu da 21% ?

FDA ta Amurka ta amince da HMB-Ca a matsayin "magungunan marayu" don maganin dystrophy na muscular Duchenne, kuma bayanan asibiti na kashi III sun nuna cewa aikin babban ga?o?in ya inganta da 28% kuma tsarin fibrosis na myocardial ya jinkirta da 19% ?

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3. Cigaba a cikin kula da cututtuka na rayuwa

Sabbin hanyoyin HMB-Ca a cikin ?a'idodin glycolipid metabolism an bayyana su:

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Insulin hankali: A cikin nau'in ciwon sukari na 2 masu ciwon sukari da aka ha?aka da HMB-Ca tsawon makonni 12, ?imar HOMA-IR ta ragu da kashi 23% kuma yawan glucose na tsoka ya karu da kashi 37%.

Gyaran metabolism mai mai: Ta hanyar kunna hanyar AMPK, abun ciki na triglyceride hanta ya ragu da kashi 29% kuma matakin adiponectin ya karu da 18%

Gut microbiota regulation: gajeriyar sarkar fatty acid samar da ya karu da 42% kuma aikin shinge na hanji ya inganta da 31% tare da canje-canje a cikin firmicutes / Bacteroides rabo ?

A cikin maganin cututtukan hanta mai ?iba, tsarin sa baki na HMB-Ca tare da silymarin ya rage makin fibrosis na hanta da maki 1.2 kuma ya ha?aka ?imar al'ada ta ALT zuwa 68%?57. Wani binciken RCT a cikin yawan jama'a tare da ciwo na rayuwa ya nuna raguwar 19% a cikin ha?arin ha?arin cututtukan zuciya (ASCVD) bayan makonni 24 na sa baki.

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4.Food bidi'a ga musamman likita dalilai

Shirye-shiryen likita na musamman bisa HMB-Ca suna sake rubuta yanayin yanayin abinci mai gina jiki na asibiti:

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Gyaran aikin tiyata na farko: A cikin marasa lafiya tare da maye gurbin ha?in gwiwa, ?arin 6 grams na HMB-Ca / rana 3 kwanaki kafin aikin tiyata zai iya inganta saurin ?arfin ?arfin tsoka na baya da sau 2.3 kuma ya rage tsawon lokacin asibiti ta kwanaki 2.5 ?

Kariyar Radiation daga ciwon daji: Kariyar abinci mai gina jiki na baka mai dauke da HMB-Ca a cikin marasa lafiya na rediyo da kai sun rage yawan kamuwa da mucositis da kashi 41% da kuma ingantaccen yanayin dandano da kashi 57%.

Tallafin abinci mai gina jiki na jarirai: ?arfafawar HMB-Ca (50mg/kg/d) a cikin dabarar jarirai da aka riga aka haifa ta ?ara girman girman jiki da kashi 24% da ?imar ci gaban neurodevelopment da kashi 19%

Hukumar kula da lafiya ta kasar Sin ta sanya HMB-Ca cikin kundin tsarin albarkatun danyen abinci na Formula don amfanin kiwon lafiya na musamman, kuma ta amince da aikace-aikacenta a cikin nau'o'in samfurori guda 6, ciki har da jimillar nau'in nau'in ciwon sukari na 8. Fasahar microsphere mai dorewa ta HMB-Ca da aka ha?aka a Japan na iya ?ara yawan sha na hanji zuwa kashi 91% kuma ya ?unsar juzu'in jujjuyawar tattara magungunan jini zuwa ± 7%

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5.Extension na wasanni gyara magani

Bayan filin abinci mai gina jiki na wasanni na gargajiya, aikace-aikacen HMB-Ca a cikin magungunan gyarawa yana ci gaba da fa?a?a:

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Gyaran raunin jijiya : A cikin marasa lafiya da raunin kashin baya, ha?in HMB-Ca da aikin motsa jiki na lantarki ya karu da yanki na yanki na ragowar ?wayar tsoka ta 17% da kuma ADL ta 23% bayan watanni 6.

farfadowa da aikin tiyata na orthopedic: bayan gyaran gyare-gyaren ligament na baya, ?arin HMB-Ca, digiri na quadriceps atrophy ya rage da 58%, dawowa zuwa motsa jiki 3-4 makonni baya ?

Aikace-aikacen magani na Aerospace: 'Yan sama jannati a tashar sararin samaniya ta ?asa da ?asa sun kara da gram 3 na HMB-Ca yau da kullun yana rage asarar tsoka a cikin microgravity da kashi 72% da adadin asarar ?ashi da kashi 39%?

A fagen kariyar raunin wasanni, HMB-Ca preconditioning regimen ya rage kololuwar creatine kinase da 44% da tsawon jinkirin ciwon tsoka da 51% bayan motsa jiki na centrifugal ?. Kungiyar kwallon kafa ta Ingila ce ta Magungunan Sports Ba da shawarar da fara shirin HMB-CA 2 makonni kafin babban taron rauni na iya rage ha?arin rauni da 37%

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6.Future frontier: Biotechnology hadewa da kuma sabon abu

Aikace-aikacen interdisciplinary na HMB-Ca yana haifar da sabbin fasahohin fasaha:

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Tsarin bayarwa na Nano: Shirye-shiryen da aka yi niyya na HMB-Ca wanda aka sanya a cikin liposome yana ?aruwa da tarawa a cikin ?wayar tsoka ta sau 3.7 kuma an tsawaita lokacin tasiri zuwa sa'o'i 72.

Shirye-shiryen nazarin halittu na roba: An rage farashin HMB-Ca da kashi 62%, tsarkin HMB-CA ya kai kashi 99.9% na ma'aunin magunguna.

Tsarin abinci mai gina jiki na dijital: na'urar da za a iya amfani da ita tana da ala?a da HMB-Ca mai wayo mai dorewa-saki facin, daidaita adadin sakin gwargwadon lokacin EMG

Nasarar gyare-gyaren Gene yana ba da damar daidaita tsarin hanyar rayuwa ta HMB, kuma CRISPR-Cas9-matsakaicin wuce gona da iri na HMB synthase ya haifar da ha?akar 29% na halitta a cikin ?wayar tsoka a cikin ?irar linzamin kwamfuta. Shirye-shiryen HMB-Ca na farko a duniya ya shiga matakin aikace-aikacen asibiti, kuma kasancewar sa ya ninka sau 2.8 sama da na nau'ikan allurai na gargajiya.

Tsaro da ?ayyadaddun aikace-aikace

Kodayake HMB-Ca yana nuna fa'idodin aikace-aikacen aikace-aikacen, har yanzu ya zama dole a lura:

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Gudanar da kashi: ana bada shawarar yin amfani da dogon lokaci kada ya wuce 5 g / rana, wuce haddi na iya haifar da rashin jin da?i na ciki.

Ha?aka lokaci: Ana ba da shawarar shan shi tare da abinci sau 2-3, kuma mafi girman maida hankali na jini ya dace da lokacin motsa jiki.

Contraindications: Dosing tare da manyan allurai na antioxidants na iya lalata hanyar mTOR

Kungiyar abinci ta Internationalungiyar abinci ta duniya (ta hanyar) shawarar da aka ba da shawarar Regimen ta nuna cewa karin haske na HMB-CA don makonni na 2-3 na samar da kyakkyawan sakamako, kuma ana iya gyara kashi na gaba zuwa 1-2 g / rana. Tare da tarin shaidun aikace-aikacen asibiti, HMB-Ca yana tasowa daga ?arin kayan abinci mai gina jiki zuwa kayan aikin dabarun dabaru da yawa, kuma iyakar ?imarsa har yanzu tana fa?a?awa.