?O ka mea mua, ?o ke olakino ?elemakule a me ka hana anti-aging

Ma ke ?ano he metabolite ko?iko?i o ka leucine, ua hō?ike ?o HMB-Ca i ka waiwai kū?oko?a i ka pale ?ana a me ka mālama ?ana i ka senile muscle decay syndrome (sarcopenia). Hō?ike ka ?ikepili ma?i i ka po?e ?elemakule ma luna o 65 mau makahiki e ho?onui i ka 3 grams o HMB-Ca i kēlā me kēia lā, i hui pū ?ia me ka ho?oma?ama?a kū?ē kū?oko?a, ma hope o 12 mau pule, ua ho?onui ?ia ka awelika nui o nā ?i?o o nā lālā e 1.2kg, pi?i ka ikaika pa?a e 14%, a hiki i ka 23%?34. Loa?a i kāna ?ano hana:

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? Ho?oulu ?ia o ke ala mTOR ? : ho?onui i ka pono o ka synthesis protein muscle e 38%.

? Kāohi ubiquitin protease system ? : ho?emi i ka hō?ike ?ana o nā hō?ailona hō?oki ?ana i ka ?i?o (e like me MuRF1) e 41%?

? Ho?oponopono i ke koena ?ā?ī ? : ho?emi i nā pae o ka mea pro-inflammatory IL-6 e 29% a ho?omaika?i i ka mumū mau loa ?

Ma ke kahua o ka anti-aging, ?o ka regimen intervention o HMB-Ca i hui pū ?ia me ka hua?a D3 i ho?olō?ihi i ka nui o ka nalowale o ka telomere e 17% a ua ho?emi ?ia nā hō?ailona huna e pili ana i ka wā kahiko (SASP) e 34%. Ke alaka?i nei ka National Longevity Medical Research Center ma Iapana i kahi ho?okolohua lapa?au o ka HMB-Ca e ho?olō?ihi i ka pi?i ?ana o ka ma?i o Alzheimer, a hō?ike ka ?ikepili mua i ka ho?omaika?i ?ana o 19% i nā helu hana cognitive ?.

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2.Construction o ka clinical nutrition support system

Ke puka mai nei ka HMB-Ca ma ke ?ano he mea?ai ko?iko?i i ka mālama ?ana i nā ma?i ho?omāinoino ko?iko?i a mau loa.

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Ka mālama ?ana i ka cachexia ma?i ma?i ma?i ma?i: ?O ka ho?ohui postoperative o 3 grams o HMB-Ca me ka omega-3 fatty acids i nā ma?i me ka ma?i ma?i colorectal hiki ke hō?emi i ka pohō o ke kino lean e 62% a ho?onui i ka ho?omanawanui ?ana i ka chemotherapy e 38%?

? Kāko?o ho?oponopono ahi ?: 30% o ka po?e ma?i wela o ke kino e ho?ohana i ka ho?omākaukau ?ana i ka mea?ai enteral i loa?a ka HMB-Ca, ua pōkole ka manawa ho'ōla ?eha e 5-7 mau lā, a ua ho?emi ?ia ka helu catabolic protein e 41%?

? ka ho?oponopono hou ?ana i ka hanu ? : Ho?ohana pū ?ia ka HMB-Ca a me nā waikawa amino branchchain i nā ma?i COPD, 6 mau mahina ma hope, ua ho?onui ?ia ka mamao hele wāwae 6 mau minuke e 82 mika, ua ho?onui ?ia ka ikaika o ka ?i?o hanu e 21%?

Ua ?ae ka US FDA i ka HMB-Ca ma ke ?ano he "lā?au makua ?ole" no ka mālama ?ana iā Duchenne muscular dystrophy, a ua hō?ike ?ia ka hō?ike hō?ike hō?ike hō?ike III i ho?omaika?i ?ia ka helu o ka lima o luna e 28% a ua ho?opane?e ke ka?ina myocardial fibrosis e 19%?

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3.Breakthrough i ka ho?okele ma?i metabolic

Ua hō?ike ?ia nā hana hou o HMB-Ca i ka ho?oponopono ?ana i ka metabolism glycolipid:

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? ?ike ?ia ka insulin ?: I nā ma?i ma?i ma?i type 2 i ho?ohui ?ia me HMB-Ca no 12 mau pule, ua ho?emi ?ia ka helu HOMA-IR e 23% a ua ho?onui ?ia ka ?ai ?ana o ka glucose i ka ?i?o iwi e 37%?

? remodeling of fat metabolism ? : Ma ka ho?oulu ?ana i ke ala AMPK, ua emi iho ka nui o ka triglyceride ate e 29% a ua ho?onui ?ia ka pae adiponectin e 18%?

? gut microbiota regulation ?: ho?onui ?ia ka ho?oulu ?ana o ka momona momona pōkole e 42% a ua ho?omaika?i ?ia ka helu hana pale ?ōpū e 31% me nā loli i ka ratio firmicutes/Bacteroides ?

I ka mālama ?ana i ka ma?i ?a?ai momona ?ole, ?o ka regimen intervention o HMB-Ca i hui pū ?ia me ka silymarin i ho?emi i ka helu fibrosis ate ma nā māka 1.2 a ho?onui i ka helu ma?amau ALT i 68%?57. Ua hō?ike ?ia kahi noi?i RCT i ka heluna kanaka me ka metabolic syndrome he 19% ka emi ?ana o ka helu pilikia o ka hanana cardiovascular (ASCVD) ma hope o 24 mau pule o ka hana.

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4.Food innovation no nā kumu lapa?au kūikawā

Ke kākau hou nei nā ?ano lā?au lapa?au kūikawā e pili ana i ka HMB-Ca i ka ?āina mea?ai olakino:

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? pre-surgical rehabilitation ? : I nā po?e ma?i me ka hui pū ?ana, ho?onui i ka 6 grams o HMB-Ca / lā 3 mau lā ma mua o ke ka?ina hiki ke ho?omaika?i i ka wikiwiki o ka ho?iho?i ?ana i ka ikaika o ka ?i?o postoperative e 2.3 mau manawa a ho?opōkole i ka lō?ihi o ka noho ma ka haukapila e 2.5 lā ?

? Ka pale ?ana i ka radiation i ka ma?i ma?i ? : ?O ka mea?ai mea?ai waha i loa?a i ka HMB-Ca ma ke po?o a me ka ?ā?ī radiotherapy nā mea ma?i i hō?emi i ka nui o ka mucositis e 41% a ho?omaika?i i nā ma?i ?ono e 57%?

? Kāko?o mea?ai mea?ai hou ? : ?O ka ho?ohui ?ana o ka HMB-Ca (50mg/kg/d) i loko o ke ?ano o nā pēpē preterm ho?onui i ke kaumaha o ke kino e 24% a me ka helu neurodevelopmental e 19%?

Ua ho?okomo ka National Health Commission o Kina i ka HMB-Ca i loko o ka Catalog of Raw Materials of Formula Food for Special Medical Use, a ua ?ae i kāna noi ?ana i 6 mau ?ano o nā huahana, ?o ia ho?i ka nui o ka mea?ai mea?ai ma?i a me ka ma?i diabetes 8. Hiki i ka ?enehana microsphere ho?oku?u ?ia ?o HMB-Ca i ho?omohala ?ia ma Iapana hiki ke ho?onui i ka nui o ka absorption intestinal i 91% a hō?emi i ka nui o ka ne?e ?ana o ka lā?au lapa?au koko i ± 7%?

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5. Ho?onui i ka lā?au ho?oponopono ha?uki

Ma waho a?e o ke kula mea?ai ha?uki ku?una, ho?onui ka noi o HMB-Ca i ka lā?au lapa?au ho?oponopono:

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? ho?oponopono ?eha nerve ? : I nā po?e ma?i me ka ?eha spinal cord, ?o ka hui pū ?ana o HMB-Ca a me ka ho?oulu ?ana i ka uila hana i ho?onui i ka ?āpana cross-sectional o ke koena pu?upu?u muscle e 17% a me ka helu ADL e 23%? ma hope o 6 mau mahina.

? ka ho?iho?i hou ?ana o ka orthopedic ?: ma hope o ke kūkulu hou ?ana i ka ligament cruciate mua, ho?ohui i ka HMB-Ca, quadriceps atrophy degere i ho?emi ?ia e 58%, ka ho?i ?ana i ka ho?oma?ama?a 3-4 mau pule ma mua ?

? Nā noi lā?au lapa?au Aerospace ? : ?O nā Astronauts ma ka International Space Station i ho?ohui ?ia me 3 grams o HMB-Ca i kēlā me kēia lā i hō?emi ?ia ka nalo ?ana o ka ?i?o i ka microgravity e 72% a me ka nui o ka poho iwi e 39%?

Ma ke kahua o ka pale ?ana i ka hō?eha ha?uki, ua hō?emi ka HMB-Ca preconditioning regimen i ka peak creatine kinase e 44% a me ka lō?ihi o ka ?eha ?ana o ka ?i?o e 51% ma hope o ka hana centrifugal ?. Mana?o ka British Association of Sports Medicine e ho?omaka i ka papahana ho?ohui HMB-Ca 2 mau pule ma mua o kahi hanana ki?eki?e e hiki ke hō?emi i ka hopena o ka hō?eha nui e 37% ?

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6.Future frontier: ?O ka ho?ohui ?ana i ka biotechnology a me ka hana hou

Ke ho?opuka nei ka noi interdisciplinary o HMB-Ca i nā paradigms ?enehana hou:

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? Nano delivery system ? : ?O ka ho?omākaukau ?ana o ka HMB-Ca i ho?opili ?ia i loko o ka liposome e ho?onui i ka hō?ili?ili ?ana i ka ?i?o ?i?o e 3.7 mau manawa a ho?onui ?ia ka manawa kūpono i 72 mau hola ?

? Ho?omākaukau biology Synthetic ? : Ua hō?emi ?ia ke kumukū?ai o HMB-Ca e 62%, ?o ka ma?ema?e o HMB-CA i hō?ea i ka 99.9% pharmaceutical grade standard ?

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Hiki i nā hanana ho?oponopono Gene ke ho?oponopono i ke ala metabolic HMB, a ?o CRISPR-Cas9-mediated overexpression o HMB synthase i hopena i ka 29% ho?onui maoli i ka nui o ka ?i?o i loko o kahi ho?ohālike ?iole ?. Ua komo ka ho?omākaukau prodrug HMB-Ca mua o ka honua i ke kahua noi?i lapa?au, a ?o kona bioavailability he 2.8 mau manawa ki?eki?e ma mua o nā ?ano hana ma?amau ?

Palekana a me nā kiko?ī noi?i

?Oiai ke hō?ike nei ?o HMB-Ca i nā mana?o noi?i ākea, pono pono e ho?omaopopo:

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Ka ho?omalu ?ana: ?a?ole ?oi aku ka nui o ka ho?ohana lō?ihi ma mua o 5 g / lā, ?oi aku ka nui o ka hō?eha ?ana i ka ?ōpū.

? Ho?oponopono manawa ? : Mana?o ?ia e lawe me ka ?ai i 2-3 mau manawa, a ?o ke ki?eki?e o ke koko koko e like me ka manawa ho?oikaika kino ?

? contraindications ? : ?O ka ho?ohana ?ana me ka nui o nā antioxidants hiki ke ho?opilikia i ka ho?āla ?ana o ke ala mTOR.

Hō?ike ka International Society of Sports Nutrition (ISSN) regimen i ka ho?ohui ?ana o HMB-Ca no 2-3 mau pule e hā?awi i nā hopena maika?i loa, a hiki ke ho?ololi ?ia ka nui o ka mālama ?ana i 1-2 g / lā ?. Me ka hō?ili?ili ?ana o nā hō?ike noi?i lapa?au, ke ulu nei ?o HMB-Ca mai kahi mea?ai mea?ai i kahi waiwai ho?olālā multi-disciplinary, a ke ho?onui mau nei kona palena waiwai.