?O ka hū beta-glucan kahi polysaccharide hana i loa?a mai ka paia o ka hū. I ka makahiki 1941, ua ?ike ?o Kauka Pillemer i kahi mea i loko o ka pā hū e ho?onui ai i ka palekana. I ka makahiki 1961, ua ?ike ?o Riggi i kēia mea hana i loko o ka yeast glycan he beta-glucan [1]. ?O nā kumu ma?amau o ka beta-glucan pū kekahi me ka oats, fungi, limu, a me nā mea ?ē a?e, no ka mea ?a?ole hiki i ke kino ke synthesize a huna i ka beta-glucan pono?ī, pono e ho?ohui ?ia e ka honua o waho.

Ma waho a?e o ka β-glucan a me ka pa hū hū he mannose wai-soluble a me kahi li?ili?i o chitin, β-glucan i helu ?ia no 30% a 60% o ke kaumaha malo?o o ka paia o ke kelepona, ma ka ?ao?ao o loko o ka paia o ka cell, nona ka polysaccharide structural, ?o ka hana physiological nui ka mālama ?ana i ka ikaika mechanical o ka paia cell. Misaki et al. Ua ?ike ?ia ?o ke ?ano o ka hū β-glucan ka nui o ka β-1, 3-bond, a aia kekahi hapa o nā koena β-1, 6-bond.

?O ka maika?i o ka immunomodulatory o ka hū beta-glucan e hilina?i ana i kāna kiko?ī kiko?ī, kona hiki ke ho?opa?a i nā mea ho?okipa kūikawā ma ka ?ili o nā cell immune, ?oiai e ho?onui ana i ka hana phagocytosis o macrophages. Ho?opau koke kēia ka?ina i ka pane ?ana o ke kino a mālama i ke koena kūpono o ka ?ōnaehana pale.

Hana nui ka Beta-glucan ma ka ho?opa?a ?ana i ?ekolu mau ?ano mea loa?a beta-glucan [4] : (1) ?O ka mea loa?a ?o Dectin-1; (2) CR3; (3) ?O nā mea loa?a ?ē a?e, e komo pū me ka scavenger receptor a me LacCer. Ke komo ka hū β-glucan i loko o ke kino o ke kanaka a ho?opa?a i ka mea ho?okipa, e ho?onui ia i ka phosphorylation o kāna intracellular immune receptor tyrosine motif (ITAM) a me Syk, a ho?āla i ke ala PI3K / Akt, ka mea e alaka?i ai i ka phagocytosis, ka make microbial a me ka ho?oku?u cytokine, i mea e ho?oka?awale maika?i ai i nā ?āpana ?ē a?e a pale i ka ho?ouka kaua ?ana. A laila loa?a iā ?oe ka hopena o ka palekana.

Hō?ike nui ?ia nā pōmaika?i olakino o ka ?ili o ka beta-glucan i kēia mau ?ao?ao [6]:

1) Hiki i ka Antioxidant: Loa?a i ka β-glucan nā waiwai antioxidant, hiki ke kāohi i ka hana o nā superoxides a me nā ?ano oxygen reactive ?ē a?e (ROS) a ho?emi i ka pō?ino o ke ko?iko?i oxidative i ka ?ili.

2) Moisturizing hopena: Me kona ki?eki?e molecular kaumaha, β-glucan i ka wai ikaika hiki ke ho?opa?a i ka wai, hiki ke ho?opili pono i nā molekele wai i ka ?ili o nā ?ili o ka ?ili, pale i ka ho?ohehe?e ?ana o ka wai, a ho?emi i ka nalowale o ka wai ma o ka epidermis (TEWL). Eia kekahi, hana ia i kahi ki?i pale ma ka ?ili o ka ?ili, e kōkua ana i ka mālama ?ana i ka makū a me ka palupalu i ka ?ili.

3) Ho?oponopono a ho'ōla i ka ?ili: Seo et al. Ua ?ike ?ia nā kumu like ?ole o ka beta-glucan hiki ke ho?oikaika i ka ne?e ?ana o nā keratinocytes kanaka (HaCaT) a me nā fibroblasts ?ili kanaka (HDFa), a ho?olalelale i ka pani ?ana i ka ?eha a me ka re-epithelialization i nā ki?i ki?i [7]. Eia kekahi, ?o nā waiwai anti-inflammatory a me nā anti-irritant o ka beta-glucan e kōkua i ka ho?omaha ?ana i ka ?ula?ula a me ka ?ula?ula a ho?omaha i ka ?ili ?eha. Ua hō?ike ?ia kahi noi?i ma ka Journal of Therapeutic Dermatology he mea ho?ohui maika?i ka beta-glucan i ka mālama ?ana i ka dermatitis atopic māmā (eczema) [8].

4) Nā hopena anti-kahiko: Kōkua ?o Beta-glucan e hō?emi i nā hō?ailona o ka ?elemakule o ka ?ili, e like me nā wrinkles a me ka sagging. Ho?oikaika ia i ka synthesis o ka collagen a me nā mea ?ē a?e extracellular matrix (ECM), ho?onui i ka mānoanoa a me ka elasticity o ka ?ili.

Eia kekahi, loa?a i ka beta-glucan ke kuleana o ka ho?oponopono ?ana i ka flora intestinal, hō?emi i ka cholesterol, anti-fatigue, olakino iwi a pēlā aku.

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