Ua ntej, cov neeg laus noj qab haus huv thiab kev tiv thaiv kev laus

Raws li ib qho tseem ceeb metabolite ntawm leucine, HMB-Ca tau qhia tshwj xeeb muaj nuj nqis nyob rau hauv kev tiv thaiv thiab kev kho mob ntawm senile leeg decay syndrome (sarcopenia). Cov ntaub ntawv kho mob qhia tau tias cov neeg laus dua 65 xyoos ntxiv 3 grams HMB-Ca txhua hnub, ua ke nrog kev cob qhia tsis zoo, tom qab 12 lub lis piam, cov leeg nqaij nruab nrab ntawm cov ceg ceg tau nce 1.2kg, tuav lub zog nce los ntawm 14%, thiab cov kauj ruam kev txhim kho nce mus txog 23% 34. Nws mechanism ntawm kev txiav txim muaj xws li:

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Ua kom txoj hauv kev mTOR: nce nqaij protein synthesis efficiency los ntawm 38%

Inhibited ubiquitin protease system : txo qhov kev qhia ntawm cov leeg nqaij tawg (xws li MuRF1) los ntawm 41%

Txhim kho qhov sib npaug ntawm qhov mob: txo qis ntawm cov tshuaj tiv thaiv kab mob IL-6 los ntawm 29% thiab txhim kho qhov mob ntev.

Hauv kev tiv thaiv kev laus, kev cuam tshuam kev tswj hwm ntawm HMB-Ca ua ke nrog cov vitamin D3 qeeb tus nqi ntawm telomere poob los ntawm 17% thiab txo cov cell aging-related secretory phenotype (SASP) cov cim los ntawm 34%. Lub National Longevity Medical Research Center hauv Nyij Pooj tab tom ua ib theem II kev soj ntsuam ntawm HMB-Ca kom qeeb qhov kev loj hlob ntawm Alzheimer's kab mob, thiab cov ntaub ntawv ua ntej qhia txog 19% kev txhim kho hauv cov qhab nia ua haujlwm.

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2.Kev tsim kho cov khoom noj khoom haus kev txhawb nqa

HMB-Ca tau tshwm sim los ua cov khoom noj tseem ceeb hauv kev kho cov kab mob tseem ceeb thiab mob ntev:

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Kev tswj mob qog noj ntshav cachexia : Postoperative supplementation ntawm 3 grams ntawm HMB-Ca nrog omega-3 fatty acids nyob rau hauv cov neeg mob uas muaj mob qog noj ntshav tuaj yeem txo qis lub cev hnyav los ntawm 62% thiab ua kom cov tshuaj tiv thaiv kab mob siab ntxiv los ntawm 38%.

Kev kho qhov kub hnyiab: 30% ntawm cov neeg mob lub cev kub hnyiab tau siv cov khoom noj khoom haus enteral uas muaj HMB-Ca, lub sijhawm kho qhov txhab yog luv luv los ntawm 5-7 hnub, thiab cov protein catabolic txo los ntawm 41%.

Daim ntawv thov kev ua pa rov ua pa: Kev siv HMB-Ca thiab branchchain amino acids hauv cov neeg mob COPD, 6 lub hlis tom qab, 6-feeb taug kev deb tau nce 82 meters, lub zog ntawm cov leeg ua pa tau nce 21%.

US FDA tau pom zoo HMB-Ca ua "cov tshuaj menyuam ntsuag" rau kev kho mob ntawm Duchenne cov leeg nqaij dystrophy, thiab cov ntaub ntawv kho mob theem III tau pom tias cov txiaj ntsig ntawm cov ceg tawv tau txhim kho los ntawm 28% thiab cov txheej txheem myocardial fibrosis ncua los ntawm 19%.

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3.Txoj kev tswj cov kab mob metabolic

Cov txheej txheem tshiab ntawm HMB-Ca hauv kev tswj hwm ntawm glycolipid metabolism tau raug nthuav tawm:

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Cov tshuaj insulin rhiab heev: Hauv cov neeg mob ntshav qab zib hom 2 ntxiv nrog HMB-Ca rau 12 lub lis piam, HOMA-IR Performance index poob los ntawm 23% thiab cov leeg nqaij pob txha noj qab haus huv nce 37%

Remodeling ntawm cov roj metabolism hauv: Los ntawm kev ua kom AMPK txoj hauv kev, daim siab triglyceride cov ntsiab lus txo los ntawm 29% thiab qib adiponectin nce 18%

Kev tswj lub plab microbiota : luv-chain fatty acid ntau lawm tau nce los ntawm 42% thiab txoj hnyuv ua haujlwm tau zoo dua los ntawm 31% nrog kev hloov pauv hauv firmicutes / Bacteroides piv.

Hauv kev kho mob ntawm cov kab mob uas tsis yog-coholic fatty siab, cov kev cuam tshuam ntawm HMB-Ca ua ke nrog silymarin txo qis daim siab fibrosis qhab nia los ntawm 1.2 qib thiab nce ALT li qub rau 68% ??57. Kev tshawb nrhiav RCT hauv cov pej xeem uas muaj cov kab mob metabolic tau pom tias 19% txo qis hauv cov kab mob plawv (ASCVD) tom qab 24 lub lis piam ntawm kev cuam tshuam.

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4.Food innovation rau kev kho mob tshwj xeeb

Cov tshuaj kho mob tshwj xeeb raws li HMB-Ca tab tom rov sau cov chaw kho mob noj zaub mov zoo:

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Kev kho mob ua ntej kev phais: Hauv cov neeg mob uas muaj kev sib koom ua ke, ntxiv 6 grams ntawm HMB-Ca / hnub 3 hnub ua ntej kev phais tuaj yeem txhim kho qhov ceev ntawm cov leeg nqaij rov qab los ntawm 2.3 zaug thiab txo qhov ntev hauv tsev kho mob los ntawm 2.5 hnub.

Kev tiv thaiv hluav taws xob tiv thaiv kab mob qog noj ntshav: Cov khoom noj hauv qhov ncauj uas muaj HMB-Ca nyob rau hauv lub taub hau thiab caj dab kho mob cov neeg mob txo qis qhov tshwm sim ntawm mucositis los ntawm 41% thiab txhim kho saj tsis zoo los ntawm 57%

Kev them nyiaj yug menyuam yug tshiab: Kev txhawb nqa ntawm HMB-Ca (50mg / kg / d) hauv cov menyuam mos yug ntxov ntxov ua rau lub cev hnyav nce li 24% thiab cov qhab nia neurodevelopmental los ntawm 19%

Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Hauv Tebchaws ntawm Tuam Tshoj tau suav nrog HMB-Ca rau hauv Cov Khoom Siv Raw Cov Khoom Noj Khoom Noj rau Kev Siv Kho Mob Tshwj Xeeb, thiab tau pom zoo nws daim ntawv thov hauv 6 pawg ntawm cov khoom, suav nrog cov qog nqaij hlav tag nrho cov zaub mov thiab cov ntshav qab zib tshwj xeeb cov khoom noj khoom haus 8. HMB-Ca sustained-tso microsphere thev naus laus zis tsim hauv Nyij Pooj tuaj yeem ua kom cov hnyuv nqus tau mus txog 91% thiab nqaim qhov sib txawv ntawm cov tshuaj ntshav siab mus rau ± 7%

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5.Extension ntawm kev ncaws pob rehabilitation tshuaj

Dhau li ntawm cov khoom noj khoom haus ib txwm muaj, daim ntawv thov ntawm HMB-Ca hauv cov tshuaj kho mob txuas ntxiv nthuav dav:

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Kev kho mob paj hlwb: Hauv cov neeg mob uas raug mob qaum qaum, kev sib xyaw ntawm HMB-Ca thiab kev ua haujlwm hluav taws xob ua kom lub cev muaj zog ntxiv rau thaj tsam ntawm cov leeg leeg los ntawm 17% thiab ADL qhab nia los ntawm 23% tom qab 6 lub hlis.

Kev phais orthopedic rov qab los: tom qab anterior cruciate ligament reconstruction, ntxiv HMB-Ca, quadriceps atrophy degree txo los ntawm 58%, rov qab mus rau kev tawm dag zog 3-4 lub lis piam ua ntej

Daim ntawv thov tshuaj Aerospace : Cov neeg nyob hauv lub tshav dav hlau thoob ntiaj teb tau ntxiv nrog 3 grams ntawm HMB-Ca txhua hnub txo cov leeg nqaij hauv microgravity los ntawm 72% thiab tus nqi ntawm cov pob txha ceev los ntawm 39%

Hauv kev tiv thaiv kev raug mob kis las, HMB-Ca preconditioning regimen txo qis creatine kinase los ntawm 44% thiab lub sijhawm ncua ntawm cov leeg mob los ntawm 51% tom qab kev tawm dag zog centrifugal. British Association of Sports Medicine pom zoo tias pib qhov kev pab cuam HMB-Ca ntxiv 2 lub lis piam ua ntej qhov kev tshwm sim muaj zog tuaj yeem txo qhov kev pheej hmoo ntawm kev raug mob hnyav los ntawm 37%

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6.Future frontier: Biotechnology integration thiab innovation

Daim ntawv thov kev sib koom tes ntawm HMB-Ca yog tsim cov txheej txheem thev naus laus zis tshiab:

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Nano kev xa khoom: Lub hom phiaj npaj ntawm HMB-Ca encapsulated hauv liposome nce cov pob txha hauv cov leeg nqaij los ntawm 3.7 npaug thiab lub sijhawm ua haujlwm tau txuas ntxiv mus rau 72 teev.

Synthetic biology npaj : Tus nqi ntawm HMB-Ca raug txo los ntawm 62%, lub purity ntawm HMB-CA mus txog 99.9% kws tshuaj qib tus qauv

Kev cuam tshuam cov khoom noj khoom haus digital: cov cuab yeej siv tau txuas nrog HMB-Ca ntse txhawb nqa-tso thaj ua haujlwm, hloov kho cov tshuaj tso tawm raws li lub sijhawm EMG

Gene editing breakthroughs ua kom muaj kev tswj hwm ntawm HMB metabolic txoj hauv kev, thiab CRISPR-Cas9-mediated overexpression ntawm HMB synthase ua rau 29% ntuj nce hauv cov leeg nqaij hauv tus qauv nas. Lub ntiaj teb thawj qhov kev npaj HMB-Ca prodrug tau nkag mus rau theem kev kho mob, thiab nws cov bioavailability yog 2.8 npaug ntau dua li cov ntawv sau tshuaj.

Kev nyab xeeb thiab daim ntawv thov specifications

Txawm hais tias HMB-Ca qhia dav dav rau daim ntawv thov, nws tseem yuav tsum tau nco ntsoov:

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Kev tswj hwm koob tshuaj: kev siv mus sij hawm ntev yog pom zoo kom tsis pub tshaj 5 g / hnub, ntau dhau yuav ua rau mob plab hnyuv.

Sijhawm optimization : Nws raug nquahu kom noj nws nrog zaub mov 2-3 zaug, thiab cov ntshav siab siab tshaj plaws yog lub sijhawm stimulation.

Contraindications: Kev noj tshuaj ntau ntawm cov tshuaj antioxidants tuaj yeem cuam tshuam rau mTOR txoj kev ua kom

Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv (ISSN) pom zoo cov txheej txheem qhia tau hais tias kev ntxiv ntawm HMB-Ca rau 2-3 lub lis piam muab cov txiaj ntsig zoo, thiab cov tshuaj kho tuaj yeem hloov kho rau 1-2 g / hnub. Nrog rau kev sib sau ua ke ntawm cov ntaub ntawv pov thawj kev kho mob, HMB-Ca tab tom hloov zuj zus los ntawm cov khoom noj khoom haus ntxiv mus rau ntau qhov kev qhuab qhia zoo tshaj plaws, thiab nws cov nqi ciam teb tseem nthuav dav.