1.Bidirectional kev tswj ntawm protein metabolism

HMB ua tiav qhov sib npaug ntawm cov leeg mob kho mob los ntawm ntau txoj hauv kev sib koom ua ke:

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mTOR teeb liab ua kom: nce ribosome S6 kinase phosphorylation theem los ntawm 38%, ceev myosin hnyav saw thiab lwm yam tseem ceeb protein synthesis efficiency

inhibitory nyhuv ntawm ubiquitination : txo qhov kev qhia ntawm E3 ubiquitin ligase MuRF1 los ntawm 41%, thiab thaiv cov txheej txheem molecular marker ntawm cov leeg nqaij.

autophagy homeostasis : Ua kom zoo dua LC3-II / LC3-I piv rau 1: 1.5 txhawm rau tiv thaiv cov nqaij fiber ntau degradation los ntawm ntau dhau autophagy

Thib ob, cell membrane tiv thaiv technology innovation

HMB txhim khu kev ruaj ntseg ntawm tes los ntawm kev cuam tshuam qib molecular:

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Cov txheej txheem membrane ntxiv dag zog rau: nce cov ntsiab lus ntawm phosphatidylinositol los ntawm 27%, txhim kho kev ua haujlwm ntawm kev ntxhov siab ntawm cov leeg nqaij.

calcium ion regulation : inhibit qhov txawv txav ntawm mitochondrial permeability hloov pore thiab txo qhov kev pheej hmoo ntawm calcium overload los ntawm 63%.

Kev tiv thaiv oxidative kev nyuaj siab: qhib Nrf2 txoj hauv kev, kev ua haujlwm ntawm superoxide dismutase (SOD) nce 41%

Iii. Cov ntaub ntawv qhia txog kev ua kis las

1.High siv kev ua kis las tiv thaiv

Cov ncaws pob ncaws pob ntxiv nrog 3 g / hnub HMB txo qhov ncov creatine kinase (CK) los ntawm 44% thiab txo lub sijhawm ntawm cov leeg mob los ntawm 51%

Tom qab 72 teev ntawm kev tawm dag zog centrifugal, qhov tshwm sim ntawm Z-line rheology ntawm cov leeg nqaij fibers raug txo los ntawm 62%, thiab cov qauv kev ncaj ncees ntawm mitochondria tau txhim kho los ntawm 83%.

2.Endurance kev ua tau zoo optimization

Hauv kev sib tw marathon, cov ntshav lactate txo qis los ntawm 19% thiab cov leeg nqaij glycogen tau nce los ntawm 27% 68

Lub voj voog 6-lub lim tiam ntxiv tau nce VO2max los ntawm 4.2% thiab nce kev tawm dag zog los ntawm 13%

4.Clinical transformation milestone

5.Kev tiv thaiv thiab kho cov leeg nqaij atrophy gravis

Hauv ICU cov neeg mob ntxiv nrog HMB rau 28 hnub, quadriceps cov leeg tuab tau khaws cia 1.3 hli ntau dua, thiab qhov ua tiav ntawm lub tshuab ua pa tawm ntawm txoj kab tau nce 31%.

Hauv cov neeg mob kub hnyiab hnyav, cov protein tawg tau qis dua 47% thiab lub sijhawm kho qhov txhab yog 5 hnub luv dua.

2.Kev cuam tshuam ntawm senile sarcopenia

Tom qab 12 lub lis piam ntawm kev cuam tshuam, qhov nrawm nrawm ntawm cov neeg laus hnub nyoog tshaj 70 xyoo tau nce los ntawm 0.15m / s, thiab kev pheej hmoo ntawm kev poob qis los ntawm 38%.

MRI tau pom tias 21% txo qis hauv intramuscular rog infiltration thiab 14% nce hauv hom II nqaij fiber ntau.

5.Cutting-edge technology innovation

Nano xa khoom system

Liposome encapsulation thev naus laus zis tau nce cov leeg lub hom phiaj siab los ntawm 3.7 npaug, thiab qhov hloov pauv ntawm cov ntshav siab yog

Lub ntse transdermal thaj ua tiav EMG cov lus teb cov cai thiab txo qis kev tso tawm qeeb rau 15 vib nas this

Kev tawg hauv cov khoom siv hluavtaws

Cov kws tsim khoom tsim tawm tau nce mus rau 8.7g / L thiab cov nqi tsim khoom raug txo los ntawm 62%

CRISPR kho tshuab nrawm nrawm kho cov leeg los ntawm 41%, nkag mus rau kev sim ua ntej

6. Kev nyab xeeb specifications

Mob toxicity: qhov ncauj LD50> 5000mg / kg hauv nas, yog tiag tiag tsis muaj tshuaj lom.

Daim ntawv thov mus sij hawm ntev: Tsis muaj tshuaj lom hepatorenal tau pom tom qab 12 lub hlis ntawm kev cuam tshuam, thiab qhov tshwm sim ntawm plab hnyuv tsis xis nyob yog

Tus txheej txheem koob tshuaj : cov neeg tawm dag zog tau pom zoo kom noj 3 g / hnub hauv cov koob tshuaj sib faib, cov tshuaj kho tau nce los ntawm cov kauj ruam

Vii. Yav tom ntej Outlook

Kev tswj hwm epigenetic: Tshawb nrhiav cov teebmeem ntawm HMB ntawm DNA methylation qauv ntawm cov leeg qia hlwb

Mechanism ntawm cov kab mob hauv zej zog kev sib cuam tshuam: Kev tshuaj xyuas lub luag haujlwm tswj hwm ntawm HMB metabolites ntawm plab hnyuv firmicutes / Bacteroides piv