?????? ???????? ?????? ??? ???????? ??????? ?? HMB Ca ?????? ?????? ??????
1. ????? ??-?????? ?? ???????? ???????
HMB ???? ????? ????? ?? ????? ?????? ?????? ??????? ????? ???????? ??-???????:
?
????? ??? mTOR: ????? ???? ?????? ?? ??????? S6 ????? ?-38%, ???? ?? ?????? ?????? ????? ???? ?? ?????? ???????? ??????? ?????.
????? ????? ?? ??????????????: ?????? ?? ?????? ?? E3 ??????????? ????? MuRF1 ?-41%, ????? ?? ????? ???? ????????? ?? ????? ??????.
?????????? ?? ????????: ??????????? ?? ??? LC3-II/LC3-I ?-1:1.5 ??? ????? ????? ???? ???? ????? ?? ??? ???????? ??????.
????, ?????? ??????????? ???? ?? ???? ???
HMB ???? ?? ?????? ??? ??????? ????????? ???? ??????????:
????? ???? ???????: ????? ????? ?????????????????? ?-27%, ????? ??????? ???? ??? ???? ?? ???? ?????.
????? ???? ????: ???? ?? ?????? ??? ????? ?? ???????? ????? ?? ?????? ???????????? ?????? ?? ?????? ????? ??? ?? ???? ?-63%
???? ???? ??? ???????: ????? Nrf2 ?????, ?????? ?????????? ???????? (SOD) ???? ?-41%
?. ?????? ???????? ?? ????? ?????
1. ???? ???? ????? ?????? ?????
????? ?????? ?????? 3 ??? HMB ???? ?????? ?? ??? ???????? ????? (CK) ?-44% ??????? ?? ??? ???? ??????? ?-51%.
???? 72 ???? ?? ?????? ?????? ???????????, ?????? ?????????? ?? ?? ?-Z ?? ???? ????? ???? ?-62%, ?????? ????? ?? ???????????? ????? ?-83%.
2. ??????????? ?? ?????? ??????
??? ??? ?????, ???? ????? ??? ???? ?-19% ?????? ???????? ??????? ???? ?-27%?68
????? ??????? ?? 6 ??????? ????? ?? ?-VO2max ?-4.2% ??? ??????? ??????? ?????? ?-13%.
4. ??? ??? ???????????? ??????
5. ????? ?????? ???????? ?????? ?????
?????? ?????? ?????? ???? ?????? ???? HMB ???? 28 ????, ???? ???? ????? ???? ???? ?-1.3 ?"? ??????, ?????? ?????? ?? ????? ???? ?? ????? ??? ?-31%.
??? ???? ?????? ????, ??? ????? ?????? ??? ???? ?-47% ???? ????? ???? ??? ??? ???? ?-5 ????.
2. ??????? ????????? ??????
???? 12 ?????? ?? ???????, ?????? ?????? ?? ?????? ??? ??? 70 ???? ?-0.15 ??? ??????, ??????? ?????? ??? ?-38%.
MRI ???? ????? ?? 21% ?????? ???? ??? ?????? ?????? ?? 14% ???? ???? ???? ???? II.
5. ?????? ????????? ??????
????? ????? ??????????
?????????? ?????????? ?? ????????? ?????? ?? ????? ???? ????? ?? 3.7, ???? ??????? ?????? ??? ???
?????? ??????????? ????? ????? ????? ????? EMG ??????? ?? ????? ?????? ?-15 ?????.
?????? ??? ????????? ???????
????? ????? ????????? ?????? ?-8.7 ???/???? ????? ?????? ???? ?-62%.
?????????? ????? CRISPR ????? ?? ????? ??????? ?-41%, ????? ???????? ???-???????
6. ???? ??????
?????? ?????: LD50 ??? ??? > 5000 ?"?/?"? ???????, ????? ???? ????.
????? ???? ????: ?? ????? ?????? ????? ???? 12 ????? ???????, ??????? ?? ????? ?????? ?????? ?????
????? ???????: ????? ?????????? ?????? ?????? ????? 3 ???/??? ????? ???????, ?????? ??????? ??? ??????.
?. ????? ??????
??????? ????????: ????? ?????? HMB ?? ????? ??????? ?? DNA ?? ??? ??? ??????
?????? ??????????? ??? ?????? ???????: ????? ?????? ????????? ?? ????????? ?? HMB ?? ??? firmicutes/Bacteroides ??????.