Choyamba, thanzi la okalamba ndi anti-aging intervention

Monga metabolite yofunika kwambiri ya leucine, HMB-Ca yawonetsa phindu lapadera popewa komanso kuchiza matenda a senile muscle decay syndrome (sarcopenia). Deta yachipatala imasonyeza kuti anthu okalamba a zaka za 65 amawonjezera magalamu a 3 a HMB-Ca tsiku ndi tsiku, kuphatikizapo maphunziro oletsa kukana, pambuyo pa masabata a 12, pafupifupi minofu ya miyendo ya miyendo inawonjezeka ndi 1.2kg, mphamvu yogwira inawonjezeka ndi 14%, ndi kusintha kwa liwiro la sitepe kufika 23% 34. Dongosolo lake limaphatikizapo:

?

Kutsegula kwa njira ya MTOR : kuchuluka kwa kaphatikizidwe ka mapuloteni a minofu ndi 38%.

Kuletsedwa kwa ubiquitin protease system : kuchepetsedwa kwa zizindikiro za kuwonongeka kwa minofu (monga MuRF1) ndi 41%

Imawongolera kuchuluka kwa kutupa: imachepetsa kuchuluka kwa pro-inflammatory factor IL-6 ndi 29% komanso imathandizira kutupa kosatha.

Pankhani yolimbana ndi ukalamba, njira yochitirapo kanthu ya HMB-Ca yophatikizidwa ndi vitamini D3 idachepetsa kuchepa kwa telomere ndi 17% ndikuchepetsa zolembera za secretory phenotype (SASP) zokhudzana ndi ukalamba ndi 34%. National Longevity Medical Research Center ku Japan ikuyesa kuyesa kwachipatala kwa gawo lachiwiri la HMB-Ca kuti achedwetse kufalikira kwa matenda a Alzheimer's, ndipo deta yoyambirira ikuwonetsa kusintha kwa 19% kwa zidziwitso zamatenda.

?

2.Kumanga dongosolo lothandizira zakudya zachipatala

HMB-Ca ikuwoneka ngati yofunika kwambiri pochiza matenda ovuta komanso osatha:

?

Kasamalidwe ka khansa ya cachexia : Kuphatikizika kwa 3 magalamu a HMB-Ca ndi omega-3 fatty acids mwa odwala khansa ya colorectal kumatha kuchepetsa kuchepa kwa thupi ndi 62% ndikuwonjezera kulolerana ndi chemotherapy ndi 38%

Thandizo lokonzanso kuwotcha: 30% ya odwala omwe amawotcha pamwamba pathupi amagwiritsa ntchito zakudya zopatsa thanzi zomwe zimakhala ndi HMB-Ca, nthawi yochiritsa bala imafupikitsidwa ndi masiku 5-7, ndipo kuchuluka kwa mapuloteni kumachepetsedwa ndi 41%

Ntchito yobwezeretsa kupuma: Kuphatikiza kugwiritsa ntchito HMB-Ca ndi nthambi za amino acid kwa odwala COPD, patatha miyezi 6, mtunda woyenda wa mphindi 6 unakula ndi 82 metres, mphamvu ya minofu yopumira idakwera ndi 21%

US FDA yavomereza HMB-Ca ngati "mankhwala amasiye" ochizira matenda a Duchenne muscular dystrophy, ndipo data yachipatala ya gawo lachitatu ikuwonetsa kuti magwiridwe antchito am'mwamba adakwera ndi 28% ndipo njira ya myocardial fibrosis idachedwa ndi 19%

?

3.Kupambana mu kasamalidwe ka matenda a metabolic

Njira zatsopano za HMB-Ca pakuwongolera kagayidwe ka glycolipid zawululidwa:

?

Kukhudzidwa kwa insulini: Odwala amtundu wa 2 shuga omwe amaphatikizidwa ndi HMB-Ca kwa milungu 12, index ya HOMA-IR idatsika ndi 23% ndipo kuchuluka kwa shuga m'magazi kumawonjezeka ndi 37%.

kukonzanso kagayidwe ka mafuta : Poyambitsa njira ya AMPK, kuchuluka kwa triglyceride m'chiwindi kunatsika ndi 29% ndipo mulingo wa adiponectin ukuwonjezeka ndi 18%

Malamulo a m'matumbo a microbiota : Kupanga mafuta afupiafupi kumawonjezeka ndi 42% ndipo chiwerengero cha matumbo chotchinga matumbo chikuwonjezeka ndi 31% ndi kusintha kwa chiwerengero cha firmicutes / Bacteroides

Pochiza matenda a chiwindi chamafuta osaledzeretsa, njira yochitirapo kanthu ya HMB-Ca kuphatikiza ndi silymarin idachepetsa kuchuluka kwa chiwindi cha chiwindi ndi ma 1.2 ndikuwonjezera kuchuluka kwa ALT mpaka 68% 57. Kafukufuku wa RCT mwa anthu omwe ali ndi matenda a metabolic adawonetsa kuchepa kwa 19% kwa chiopsezo cha matenda amtima (ASCVD) pambuyo pa milungu 24 yolowererapo.

?

4.Food zatsopano pazifukwa zapadera zachipatala

Mapangidwe apadera azachipatala otengera HMB-Ca akulembanso mawonekedwe azachipatala:

?

Kukonzanso kusanachitike opaleshoni : Odwala omwe ali ndi malo olowa m'malo, kuwonjezera 6 magalamu a HMB-Ca/tsiku 3 masiku atatu opaleshoni isanachitike imatha kupititsa patsogolo kuchira kwamphamvu kwa minofu pambuyo pa nthawi ya 2.3 ndikufupikitsa kutalika kwa chipatala ndi masiku 2.5

Chitetezo cha radiation ku khansa : Zakudya zopatsa thanzi zomwe zili ndi HMB-Ca pamutu ndi khosi odwala radiotherapy amachepetsa kuchuluka kwa mucositis ndi 41% komanso kusokoneza kukoma ndi 57%

Thandizo la zakudya zopatsa ana obadwa kumene : Kuphatikizika kwa HMB-Ca (50mg/kg/d) m’zakudya za ana obadwa kumene kumawonjezera kulemera kwa thupi ndi 24% ndi kuchuluka kwa neurodevelopmental ndi 19%

National Health Commission of China yaphatikiza HMB-Ca mu Catalogue of Raw Equipment of Formula Food for Special Medical Use, ndipo idavomereza kuti igwiritsidwe ntchito m'magulu 6 azinthu, kuphatikiza chakudya chokwanira cha chotupa ndi matenda a shuga 8. Ukadaulo wa HMB-Ca wokhazikika wotulutsidwa ku Japan ukhoza kukulitsa mayamwidwe amatumbo mpaka 91% ndikuchepetsa kusinthasintha kwa kuchuluka kwa mankhwala amagazi mpaka ± 7%

?

5.Kuwonjezera mankhwala okonzanso masewera

Kupitilira gawo lazakudya zamasewera azikhalidwe, kugwiritsa ntchito HMB-Ca mumankhwala ochiritsira kukupitilira kukula:

?

Kubwezeretsa kuvulala kwa mitsempha : Odwala omwe ali ndi vuto la msana, kuphatikiza kwa HMB-Ca ndi kukondoweza kwamagetsi kumawonjezera gawo lamagulu otsala a minofu ndi 17% ndi chiwerengero cha ADL ndi 23% pambuyo pa miyezi 6.

Kuchira kwa opaleshoni ya mafupa : pambuyo pokonzanso mitsempha ya m'mbuyo, kuwonjezera HMB-Ca, digiri ya quadriceps atrophy yachepetsedwa ndi 58%, kubwerera ku masewera olimbitsa thupi masabata 3-4 m'mbuyomo.

Kugwiritsa ntchito mankhwala a Aerospace : Oyenda mumlengalenga pa International Space Station owonjezera ndi magalamu a 3 a HMB-Ca tsiku lililonse amachepetsa kutayika kwa minofu mu microgravity ndi 72% komanso kutayika kwa mafupa ndi 39%

Pankhani yoteteza kuvulala kwamasewera, HMB-Ca preconditioning regimen idachepetsa nsonga ya creatine kinase ndi 44% komanso kutalika kwa kuchedwa kwa minofu ndi 51% pambuyo pochita masewera olimbitsa thupi. Bungwe la British Association of Sports Medicine limalimbikitsa kuti kuyambitsa pulogalamu yowonjezera ya HMB-Ca masabata a 2 chisanachitike chochitika champhamvu kwambiri chingachepetse chiopsezo cha kuvulala kwakukulu ndi 37%

?

6.Future frontier: Kuphatikiza kwa Biotechnology ndi luso

Kugwiritsiridwa ntchito kwa HMB-Ca m'magulu osiyanasiyana kumabweretsa malingaliro atsopano aukadaulo:

?

Nano Delivery System : Kukonzekera kokonzekera kwa HMB-Ca yotsekedwa mu liposome kumawonjezera kudzikundikira kwa minofu ndi nthawi za 3.7 ndipo nthawi yogwira ntchito imakulitsidwa mpaka maola 72.

Kukonzekera kwa biology : Mtengo wa HMB-Ca unachepetsedwa ndi 62%, chiyero cha HMB-CA chinafika pa 99.9% muyeso wa mankhwala.

Kuthandizira pazakudya za digito : chipangizo chovala cholumikizidwa ndi HMB-Ca chigamba chokhazikika chokhazikika, sinthani mlingo wotulutsidwa molingana ndi EMG yeniyeni

Kusintha kwa ma gene kumathandizira kuwongolera njira ya kagayidwe kachakudya ya HMB, ndipo CRISPR-Cas9-mediated overexpression ya HMB synthase idapangitsa kuti 29% yachilengedwe ichuluke minofu mumtundu wa mbewa. Kukonzekera koyamba kwa mankhwala a HMB-Ca padziko lonse lapansi kwalowa m'malo ogwiritsira ntchito zachipatala, ndipo bioavailability yake ndi yokwera nthawi 2.8 kuposa yamitundu yanthawi zonse.

Chitetezo ndi kagwiritsidwe ntchito

Ngakhale HMB-Ca ikuwonetsa mwayi wogwiritsa ntchito, ndikofunikira kudziwa:

?

Kuwongolera mlingo: kugwiritsa ntchito nthawi yayitali ndikulimbikitsidwa kusapitilira 5 g / tsiku, kuchulukirachulukira kungayambitse kusapeza bwino kwa m'mimba.

Kukhathamiritsa kwa nthawi : Ndikoyenera kuti mutenge ndi chakudya 2-3 nthawi, ndipo kuchuluka kwa magazi m'magazi kumayenderana ndi nthawi yolimbitsa thupi.

contraindications : Kumwa mowa wambiri wa antioxidants kungayambitse kuyambika kwa njira ya mTOR.

Bungwe la International Society of Sports Nutrition (ISSN) linalimbikitsa regimen ikuwonetsa kuti kuwonjezera kwa HMB-Ca kwa masabata a 2-3 kumapereka zotsatira zabwino kwambiri, ndipo mlingo wokonzekera ukhoza kusinthidwa kukhala 1-2 g / tsiku. Ndi kuchuluka kwa umboni wogwiritsa ntchito zachipatala, HMB-Ca ikusintha kuchoka pazakudya zopatsa thanzi kupita kuzinthu zosiyanasiyana zogwirira ntchito, ndipo malire ake akukulirakulirabe.