Ubwa mbere, ubuzima bwabasaza hamwe no kurwanya gusaza

Nka metabolite yingenzi ya leucine, HMB-Ca yerekanye agaciro kihariye mukurinda no kuvura syndrome de musile yangirika (sarcopenia). Amakuru y’ubuvuzi yerekana ko abantu bageze mu za bukuru barengeje imyaka 65 bongeraho garama 3 za HMB-Ca buri munsi, hamwe n’amahugurwa arwanya ubukana, nyuma yibyumweru 12, impuzandengo yimitsi yingingo yiyongereyeho 1,2 kg, imbaraga zo gufata ziyongereyeho 14%, naho umuvuduko wo gutera intambwe wageze kuri 23% 34. Uburyo bwibikorwa bukubiyemo:

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? Gukora inzira ya mTOR ?: kongera imitsi ya protein ikora neza ya 38% ?

? Kubuza sisitemu ya protease ya ubiquitin ?: yagabanije imvugo yerekana ibimenyetso bimeneka imitsi (nka MuRF1) 41% ?

? Igenga uburinganire bwumuriro ?: igabanya urwego rwibintu bitera IL-6 kuri 29% kandi bigateza umuriro udakira ?

Mu rwego rwo kurwanya gusaza, gahunda yo gutabara HMB-Ca ifatanije na vitamine D3 yagabanije umuvuduko wo gutakaza telomere ku kigero cya 17% kandi igabanya ibimenyetso by’ibanga rya selile (SASP) byangiza imyaka 34% ?. Ikigo cy’igihugu gishinzwe ubushakashatsi ku buvuzi mu gihe cy’Ubuyapani kirimo gukora ikizamini cya kabiri cy’amavuriro ya HMB-Ca kugira ngo umuvuduko w’indwara ya Alzheimer ugabanuke, kandi amakuru abanza yerekana ko 19% byazamutse mu manota y’imikorere y’ubwenge ?.

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2.Kubaka sisitemu yo gushyigikira imirire yubuvuzi

HMB-Ca igaragara nkintungamubiri zingenzi mu kuvura indwara zikomeye kandi zidakira:

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Management Ubuyobozi bwa kanseri cachexia ?: Kwiyongera nyuma yibikorwa bya garama 3 za HMB-Ca hamwe na omega-3 fatty acide kubarwayi barwaye kanseri yibara irashobora kugabanya gutakaza umubiri mubi 62% kandi byongera kwihanganira chimiotherapie 38% ?

Gutwika inkunga yo gusana:

? Porogaramu yo gusubiza mu buzima busanzwe ubuhumekero:

FDA yo muri Amerika yemeje ko HMB-Ca ari "imiti y'imfubyi" yo kuvura dystrofi ya Duchenne imitsi, kandi amakuru yo mu cyiciro cya gatatu y’amavuriro yerekanaga ko amanota yo mu gihimba cyo hejuru yazamutseho 28% naho inzira ya fiboside ya myocardial yatinzeho 19% ?

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3.Iterambere mu micungire yindwara ya metabolike

Uburyo bushya bwa HMB-Ca mu kugenzura metabolisme ya glycolipide bwagaragaye:

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Ins insulitifike ya insuline ?: Mu barwayi ba diyabete yo mu bwoko bwa 2 hiyongereyeho HMB-Ca mu byumweru 12, indangagaciro ya HOMA-IR yagabanutseho 23% naho glucose ifata imitsi ya skeletale yiyongereyeho 37% ?

Kuvugurura ibinure bya metabolism ?: Mugukoresha inzira ya AMPK, umwijima triglyceride wagabanutseho 29% naho urwego rwa adiponectine rwiyongereyeho 18% ?

Gutunganya microbiota gutunganyirizwa ?: umusaruro wa acide ya fatty acide yiyongereyeho 42% naho amanota yimikorere yo munda amanota yazamutseho 31% hamwe nimpinduka zifatika / Ikigereranyo cya Bacteroide ?

Mu kuvura indwara z’umwijima zidafite inzoga, gahunda yo gutabara HMB-Ca ifatanije na silymarin yagabanije amanota ya fibrosis yumwijima amanota 1.2 kandi byongera igipimo cya ALT kigera kuri 68% ? 57. Ubushakashatsi bwakozwe na RCT mu baturage bafite syndrome de metabolike bwerekanye ko 19% byagabanutse ku manota y’indwara zifata umutima (ASCVD) nyuma y'ibyumweru 24 byo gutabara ?

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4.Ivugurura ryiza kubikorwa byihariye byubuvuzi

Ubuvuzi bwihariye bushingiye kuri HMB-Ca burimo kwandika imiterere yimirire yubuvuzi:

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? Mbere yo kubagwa mbere yo kubagwa ?: Mu barwayi bafite gusimburana hamwe, kongeramo garama 6 za HMB-Ca / umunsi iminsi 3 mbere yo kubagwa bishobora kongera umuvuduko wo gukira imitsi nyuma yo gukira inshuro 2,3 kandi bikagabanya uburebure bwibitaro iminsi 2.5 ?

Kurinda imirasire irinda kanseri ?: Ibiryo byuzuye mu kanwa birimo HMB-Ca mu barwayi ba radiotherapi yo mu mutwe no mu ijosi byagabanije kwandura mucosite ku kigero cya 41% kandi byongera uburyohe bwa 57% ?

Infashanyo yimirire ikivuka ?: Kuzuza HMB-Ca (50mg / kg / d) mumata atagejeje igihe byongera ibiro byumubiri kwiyongera 24% naho amanota ya neurodevelopmental 19%

Komisiyo y’ubuzima y’Ubushinwa yashyize HMB-Ca muri Cataloge y’ibikoresho fatizo by’ibiribwa bikoreshwa mu buvuzi budasanzwe, kandi yemeza ko izashyirwa mu bikorwa mu byiciro 6 by’ibicuruzwa, birimo ibibyimba byuzuye by’imirire hamwe na diyabete byihariye by’imirire ?8. Ikoranabuhanga rya HMB-Ca rihoraho-rirekura ikoranabuhanga ryakozwe mu Buyapani rishobora kongera igipimo cyo kwinjiza amara kugera kuri 91% kandi bikagabanya ihindagurika ry’ibiyobyabwenge by’amaraso bikagera kuri ± 7% ?

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5.Kwagura imiti ivura siporo

Kurenga imirire gakondo yimirire ya siporo, ikoreshwa rya HMB-Ca mubuvuzi bwo gusubiza mu buzima bukomeje kwaguka:

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? Gukomeretsa imitsi y’imitsi ?: Mu barwayi bafite ibikomere by’umugongo, guhuza HMB-Ca hamwe no gukurura amashanyarazi bikora byongereye igice cyambukiranya igice cy’imitsi isigaye ku gipimo cya 17% naho ADL amanota 23% ? nyuma y’amezi 6

? Kubaga amagufwa yo kubaga ?: nyuma yo kwiyubaka kwa ligamenti imbere, kongeraho HMB-Ca, impamyabumenyi ya quadriceps yagabanutseho 58%, kugaruka kumyitozo ibyumweru 3-4 mbere ?

Porogaramu y'ubuvuzi bwo mu kirere ?: Abashinzwe icyogajuru kuri sitasiyo mpuzamahanga yongerewe na garama 3 za HMB-Ca buri munsi bagabanije gutakaza imitsi muri microgravitike 72% naho igipimo cyo gutakaza amagufwa 39% ?

Mu rwego rwo kurinda imvune za siporo, gahunda ya HMB-Ca ibanziriza kugabanya impanuka ya creine kinase ku kigero cya 44% naho igihe cyo gutinda kubabara imitsi ku kigero cya 51% nyuma yimyitozo ngororamubiri ?. Ishyirahamwe ry’imikino ngororamubiri mu Bwongereza rirasaba ko gutangira gahunda y’inyongera ya HMB-Ca ibyumweru 2 mbere y’uko ubukana bukabije bushobora kugabanya ibyago byo gukomeretsa bikabije 37% ?

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6.Umupaka w'ejo hazaza: Guhuza ibinyabuzima no guhanga udushya

Porogaramu zitandukanye za HMB-Ca zirimo kubyara tekinoloji nshya:

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? Sisitemu yo gutanga Nano:

? Gutegura ibinyabuzima bya sintetike ?: Igiciro cya HMB-Ca cyaragabanutseho 62%, ubuziranenge bwa HMB-CA bwageze kuri 99.9% by’imiti y’imiti ?

? Imikoreshereze yimirire ya digitale ?: igikoresho gishobora kwambarwa gihuza HMB-Ca ubwenge burambye-burekura, uhinduranya cyane igipimo cyo gusohora ukurikije igihe nyacyo EMG ?

Guhindura ibisekuruza byafasha kugenzura inzira ya metabolike ya HMB, kandi CRISPR-Cas9-yunganirwa no gukabya gukabije kwa synthase ya HMB byatumye ubwiyongere busanzwe bwa 29% bwimitsi yimitsi muburyo bwimbeba ?. Kwitegura prodrug ya mbere ya HMB-Ca ku isi byinjiye mu cyiciro cyo gusaba kwa muganga, kandi bioavailable yayo irikubye inshuro 2,8 ugereranije n’uburyo bwa dosiye gakondo ?

Umutekano nibisabwa

Nubwo HMB-Ca yerekana ibyifuzo byinshi byo gusaba, biracyakenewe ko tumenya:

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Igenzura ryimiti ?: gukoresha igihe kirekire birasabwa kutarenza 5 g / kumunsi, kurenza urugero birashobora gutera uburibwe bwa gastrointestinal ?

? Igihe cyiza cyo gukora ?: Birasabwa kuyijyana nifunguro inshuro 2-3, kandi umuvuduko wamaraso uhuye nigihe cyo gukangura imyitozo ?

Kurwanya imiti ?: Kunywa hamwe na dosiye nyinshi ya antioxydants birashobora kubangamira imikorere ya mTOR ?

Umuryango mpuzamahanga wimirire yimikino (ISSN) wasabye gahunda yerekana ko kuzuza HMB-Ca ibyumweru 2-3 bitanga ibisubizo byiza, kandi igipimo cyo kubungabunga gishobora guhinduka kugeza kuri 1-2 g / kumunsi ?. Hamwe no gukusanya ibimenyetso bifatika byo kwa muganga, HMB-Ca igenda ihinduka kuva ku ndyo yintungamubiri igahinduka ibintu byinshi bifatika, kandi imbibi zayo ziracyaguka ?