Mu 1832, umuhanga mu bya shimi w’Abafaransa, Michel Eug è ne Chevreul yavumbuye bwa mbere ibiremwa mu mitsi ya skeletale, byaje kwitwa "Creatine" nyuma y’ijambo ry'ikigereki "Kreas" (inyama). Creatine ibikwa cyane mubice byimitsi, bishobora kugabanya umunaniro wimitsi no guhagarika umutima, kongera imitsi yimitsi, gutuma imitsi ikomera, kwihutisha intungamubiri za proteyine mumubiri wumuntu, kugabanya cholesterol, lipide yamaraso, hamwe nisukari yamaraso, gutinda gusaza, kandi bigira uruhare mugihe ingufu zikenewe cyane. Mu kuzuza ibiremwa, umubiri wumuntu urashobora kongera ububiko bwa creine, kuzamura urwego rwa fosifore mu mitsi, kandi bikongerera imbaraga imyitozo ngororamubiri mugihe gito, yimbaraga nyinshi. Ubushakashatsi bwerekanye ko inyongeramusaruro zidashobora kudindiza umunaniro wimitsi gusa, kunoza imbaraga ziturika zabakinnyi no kwihangana, ariko kandi binafasha kuzamura imikurire no gukira, bityo bikaba intungamubiri nziza kubakunzi ba fitness hamwe nabakinnyi.