1.Gutegekanya ibyerekezo bya protein metabolism

HMB igera ku ntera ishimishije yo gukomeretsa imitsi binyuze mu bikorwa byinshi-guhuza ibikorwa ?:

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?MTOR yerekana ibimenyetso ?: yiyongereyeho ribosome S6 kinase ya fosifora kurwego rwa 38%, yihutisha urunigi ruremereye rwa myosin hamwe nizindi ntungamubiri za poroteyine.

Ingaruka zo kubuza abantu hose ?: yagabanije imvugo ya E3 ubiquitin ligase MuRF1 ku kigero cya 41%, kandi ihagarika inzira ya marike ya marike yo kumeneka imitsi ?

? autophagy homeostasis ?: Hindura igipimo cya LC3-II / LC3-I kuri 1: 1.5 kugirango wirinde kwangirika kwimitsi yimitsi iterwa na autofagy ikabije ?

Icya kabiri, ingirabuzimafatizo zo kurinda udushya

HMB itezimbere ingirabuzimafatizo binyuze murwego rwa molekulari:

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Imiterere ya membrane ikomeza ?: kongera ibice bya fosifatiidilinositol ku gipimo cya 27%, kunoza uburyo bwo guhangana ningutu yimitsi yimitsi.

? Igenzura rya calcium ion ?: kubuza gufungura bidasanzwe imitsi yinzibacyuho ya mitochondial no kugabanya ibyago byo kurenza urugero rwa calcium 63% ?

? Kurinda impungenge za okiside ?: gukora inzira ya Nrf2, ibikorwa byo guhagarika superoxide (SOD) byiyongereyeho 41% ?

Iii. Amakuru afatika yubuvuzi bwa siporo

1.Uburemere bukomeye bwo kurinda siporo

Abakinnyi b'umupira w'amaguru biyongeraho 3 g / kumunsi HMB yagabanije peak creine kinase (CK) 44% kandi igabanya igihe cyo kubabara imitsi 51% ?

Nyuma yamasaha 72 yimyitozo ngororamubiri, indwara ya Z-umurongo wa rheologiya ya fibre yimitsi yagabanutseho 62%, kandi uburinganire bwimiterere ya mitochondriya bwongerewe 83% ?

2.Imikorere myiza yo kwihangana

Mu kwiruka muri marato, urugero rwa lakate mu maraso rwaragabanutseho 19% naho ububiko bwa glycogene bwiyongereyeho 27% ?68

Icyumweru 6 cyuzuzanya cyongereye VO2max kuri 4.2% kandi kwihanganira imyitozo byiyongereyeho 13% ?

4.Intambwe yo guhindura ibintu

5.Kwirinda no kuvura imitsi atrophy gravis

Mu barwayi ba ICU hiyongereyeho HMB mu minsi 28, umubyimba wa quadriceps wagumishijwe hejuru ya 1,3mm, kandi intsinzi ya ventilator itari kumurongo yiyongereyeho 31% ?

Mu barwayi batwitse cyane, igipimo cya poroteyine cyagabanutseho 47% naho igihe cyo gukira igikomere cyari iminsi 5 ?

2.Kwinjiza sarcopenia ya senile

Nyuma yibyumweru 12 byo gutabara, umuvuduko wo kugenda wabasaza barengeje imyaka 70 wiyongereyeho 0.15m / s, kandi ibyago byo kugwa byagabanutseho 38% ?

MRI yerekanye ko igabanuka rya 21% ryibinure byinjira mumyanya ndangagitsina no kwiyongera kwa 14% mubice byimitsi ya fibre II

5.Gukata udushya twikoranabuhanga

Sisitemu yo gutanga Nano ?

Ikoranabuhanga rya Liposome ryongereye intego yo kwikuramo imitsi inshuro 3,7, kandi ihindagurika ryamaraso ryabaye

Ubwenge bwa transdermal patch bugera kubisubizo bya EMG kandi bigabanya gutinda kurekura amasegonda 15 ?

Iterambere muri biologiya yubukorikori ?

Umusaruro wa injeniyeri wongerewe kugeza kuri 8.7g / L naho umusaruro wagabanutseho 62% ?

Ikoranabuhanga rya CRISPR ryihutisha gusana imitsi 41%, ryinjira mubigeragezo ?

6.Ibisobanuro birambuye

? Uburozi bukabije ?: umunwa LD50> 5000mg / kg mu mbeba, mubyukuri ntabwo ari uburozi ?

? Gukoresha igihe kirekire:

Dose igipimo gisanzwe ?: imyitozo yabaturage irasabwa gufata 3 g / kumunsi mukigero cyagabanijwe, imiti yo kuvura yiyongera ku ntambwe ?

Vii. Ibizaza

? Igenamigambi rya epigenetike ?: Gutohoza ingaruka za HMB ku miterere ya ADN ya methylation ya selile ingirangingo z'imitsi ?

Uburyo bukoreshwa mu mikoranire ya bagiteri ?: Isesengura ry'uruhare rugenga metabolite ya HMB ku mitsi yo mu nda / Ikigereranyo cya Bacteroide ?