Kutanga, hutano hwevakwegura uye kupindira kwekukwegura

Seyakakosha metabolite ye leucine, HMB-Ca yakaratidza kukosha kwakasiyana mukudzivirira uye kurapwa kwe senile muscle decay syndrome (sarcopenia). Data yekiriniki inoratidza kuti vanhu vakura vanopfuura makore makumi matanhatu neshanu vanowedzera 3 magiramu eHMB-Ca zuva nezuva, yakasanganiswa neane mwero kudzidziswa kudzidziswa, mushure memavhiki e12, avhareji yemhasuru yemakumbo emakumbo yakawedzera ne1. Maitiro ayo ekuita anosanganisira:

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Kuitwa kweMTOR nzira: yakawedzera tsandanyama protein synthesis kunyatsoshanda ne38%.

Inhibited ubiquitin protease system : yakaderera kutaura kwezviratidzo zvekuputsika kwemhasuru (zvakadai seMuRF1) ne41%

Inogadzirisa kuzvimba chiyero: inoderedza mazinga e-pro-inflammatory factor IL-6 ne29% uye inovandudza kuzvimba kusingaperi.

Mundima yekurwisa kuchembera, chirongwa chekupindira cheHMB-Ca chakasanganiswa nevhitamini D3 chakadzora mwero wekurasikirwa kwetelomere ne17% uye kuderedza kuchembera kwesero-related secretory phenotype (SASP) mamaki ne34%. National Longevity Medical Research Center muJapan iri kuita chikamu chechipiri chekiriniki kuyedza yeHMB-Ca kunonotsa kufambira mberi kwechirwere cheAlzheimer, uye data rekutanga rinoratidza kuvandudzwa kwe19% yezvibodzwa zvecognitive function.

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2.Kuvaka kwekiriniki yehutano hwekutsigira system

HMB-Ca iri kubuda sechikafu chakakosha mukurapa kwezvirwere zvakakomba uye zvisingaperi zvekurasa:

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cancer cachexia management : Postoperative yekuwedzera ye3 gramu yeHMB-Ca ine omega-3 fatty acids muvarwere vane colorectal cancer inogona kuderedza kuonda kwemuviri kurasikirwa ne62% uye kuwedzera chemotherapy kushivirira ne38%

Rutsigiro rwekugadzirisa kupisa: 30% yevarwere vanopisa muviri vanoshandisa gadziriro yekudya kwemukati ine HMB-Ca, nguva yekupora ronda inopfupikiswa nemazuva 5-7, uye chiyero cheprotein catabolic chinodzikiswa ne41%

Kushandiswa kwekufema kudzoreredza kufema : Kusanganiswa kushandiswa kweHMB-Ca uye branchchain amino acids muvarwere veCOPD, mwedzi mitanhatu gare gare, nhambwe yekufamba kwemaminetsi matanhatu yakawedzera nemamita makumi masere nemaviri, simba retsandanyama yekufema rakawedzera ne21%

US FDA yakatendera HMB-Ca se "mushonga wenherera" wekurapa Duchenne muscular dystrophy, uye chikamu chechitatu chekiriniki data yakaratidza kuti chikamu chepamusoro chebasa remugumbo chakavandudzwa ne28% uye myocardial fibrosis process yakanonoka ne19%

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3.Breakthrough in metabolic disease management

Maitiro matsva eHMB-Ca mukugadzirisa glycolipid metabolism akaburitswa:

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insulin senitivity: Murudzi rwechipiri chirwere cheshuga chakawedzerwa neHMB-Ca kwemavhiki gumi nemaviri, HOMA-IR index yakaderera ne23% uye skeletal muscle glucose kudya kwakawedzera ne37%.

Kugadziridza kwemafuta metabolism : Nekuita AMPK nzira, chiropa triglyceride yemukati yakaderera ne29% uye adiponectin level yakawedzera ne18%

gut microbiota regulation : short-chain fatty acid production yakawedzera ne42% uye intestinal barrier function score yakavandudzwa ne31% nekuchinja kwe firmicutes / Bacteroides ratio.

Mukurapa kwechiropa chisingaiti chirwere chechiropa, chirongwa chekupindira cheHMB-Ca chakasanganiswa ne silymarin chakaderedza chiropa che fibrosis ne 1.2 mamakisi uye yakawedzera ALT yakajairika kusvika 68% 57. Chidzidzo cheRCT muhuwandu hwevanhu vane metabolic syndrome yakaratidza kuderedzwa kwe19% mumoyo wechiitiko chiitiko chengozi (ASCVD) mushure memavhiki makumi maviri nemana ekupindira.

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4.Food innovation kune zvakakosha zvekurapa zvinangwa

Magadzirirwo ekurapa akakosha akavakirwa paHMB-Ca ari kunyorazve mamiriro ehutano hwekiriniki:

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pre-kuvhiyiwa rehabilitation : Muvarwere vane majoini kutsiva, kuwedzera 6 magiramu eHMB-Ca/zuva 3 mazuva asati avhiyiwa anogona kuvandudza kukurumidza kwemashure ekuvhiyiwa simba kupora ne2.3 nguva uye kupfupisa kureba kwekugara muchipatara nemazuva 2.5.

Kudzivirirwa kweRadiation kubva kugomarara : Oral nutritional supplement ine HMB-Ca mumusoro nemutsipa radiotherapy varwere vakaderedza kuitika kwemucositis ne41% uye kwakavandudza kuravira ne57%

Rutsigiro rwekudya kunovaka muviri : Kuwedzerwa kweHMB-Ca (50mg/kg/d) mufomu yemwana asati azvarwa yakawedzera huremu hwemuviri ne24% uye neurodevelopmental score ne19%

National Health Commission yeChina yakabatanidza HMB-Ca muCatalog yeRaw Materials yeFomula Chikafu cheSpecial Medical Use, uye yakabvumidza kushandiswa kwayo muzvikamu zvitanhatu zvezvigadzirwa, zvinosanganisira bundu rakakwana rekudya fomula uye chirwere cheshuga chakakwana chekudya kwakakwana. Iyo HMB-Ca yakaramba ichiburitsa microsphere tekinoroji yakagadziridzwa muJapan inogona kuwedzera intestinal absorption kusvika 91% uye kuderedza kushanduka kwehuwandu hwehuwandu hwemishonga yeropa kusvika ± 7%

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5.Kuwedzerwa kwemishonga yekuvandudza mitambo

Pamusoro penzvimbo yechinyakare yemitambo yekudya, kushandiswa kweHMB-Ca mumushonga wekuvandudza kunoramba kuchiwedzera:

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kukuvara kwetsinga rehabilitation : Muvarwere vane musana wekukuvara kwemusana, kusanganiswa kweHMB-Ca uye kushanda kwemagetsi kukurudzira kwakawedzera nzvimbo yepamuchinjikwa yeboka rasara remasuru ne17% uye ADL chikamu ne23% mushure memwedzi mitanhatu.

kuvhiyiwa kwemapfupa kupora : mushure me anterior cruciate ligament reconstruction, kuwedzera HMB-Ca, quadriceps atrophy degree yakaderedzwa ne58%, kudzokera kumitambo 3-4 mavhiki apfuura

Zvishandiso zvemushonga wemuchadenga : Vazivi vemuchadenga paInternational Space Station vakawedzerwa ne3 gramu eHMB-Ca zuva nezuva vakaderedza kurasikirwa kwemhasuru mumicrogravity ne72% uye mwero wekurasikirwa kwemapfupa ne39%

Mundima yekuchengetedzwa kwekukuvara kwemitambo, HMB-Ca preconditioning regimen yakaderedza peak creatine kinase ne 44% uye nguva yekunonoka kurwadza kwemasuru ne51% mushure mekuita centrifugal. Sangano reBritish Association of Sports Medicine rinokurudzira kuti kutanga chirongwa cheHMB-Ca chekuwedzera mavhiki maviri pamberi pechiitiko chepamusoro-soro chinogona kuderedza njodzi yekukuvara kwakanyanya ne37%

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6.Future frontier: Biotechnology kubatanidzwa uye innovation

Iko kushandiswa kwekudyidzana kweHMB-Ca kuri kuburitsa tekinoroji paradigms:

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Nano delivery system : Kugadzirira kwakanangwa kweHMB-Ca yakavharirwa mu liposome inowedzera kuunganidzwa kwemhasuru tishu ne3.7 nguva uye nguva inoshanda inowedzerwa kusvika kumaawa 72.

Synthetic biology kugadzirira : Mutengo weHMB-Ca wakaderedzwa ne62%, kuchena kweHMB-CA kwakasvika 99.9% yegiredhi remishonga.

kupindira kwekudya kwedhijitari: mudziyo unopfekeka wakabatana neHMB-Ca smart yakasimudzwa-kuburitsa chigamba, zvine simba gadzirisa iyo yekuburitsa dosi zvinoenderana nechaiyo-nguva EMG

Gene editing budiriro inogonesa kutonga kweHMB metabolic nzira, uye CRISPR-Cas9-mediated overexpression yeHMB synthase yakakonzera kuwedzera kwe29% kwechisikigo kwemhasuru mumodhi. Yekutanga pasi rose HMB-Ca gadziriro yemishonga yapinda mukiriniki yekushandisa nhanho, uye bioavailability yayo yakakwira zvakapetwa ka2.8 pane iyo yemaitiro echinyakare dosage .

Chengetedzo uye mashandisirwo emashandisirwo

Kunyangwe HMB-Ca ichiratidza tarisiro yakakura yekushandisa, zvichiri madikanwa kuziva:

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Kudzora dose: kushandiswa kwenguva refu kunokurudzirwa kusapfuudza 5 g / zuva, kuwandisa kunogona kukonzera kusagadzikana kwemudumbu.

Kugadzirisa nguva : Inokurudzirwa kuitora nekudya 2-3 nguva, uye huwandu hwepamusoro hweropa hunoenderana nenguva yekukurudzira kurovedza muviri.

contraindications : Kutora nemishonga yakakura ye antioxidants inogona kukanganisa mTOR nzira activation.

Sangano reInternational Society of Sports Nutrition (ISSN) rinokurudzira regimen inoratidza kuti kuwedzera kweHMB-Ca kwemavhiki e2-3 kunopa mhedzisiro yakakwana, uye dosi rekuchengetedza rinogona kugadziridzwa kusvika 1-2 g/zuva. Nekuunganidzwa kwehumbowo hwekushandisa kwekiriniki, HMB-Ca iri kusimuka kubva kune yekuwedzera chikafu ichienda kune yakawanda-disciplinary strategic functional substance, uye kukosha kwayo kuchiri kuwedzera.