Okokuqala, impilo yabantu abadala kunye nokungenelela kokuguga

Njenge-metabolite ephambili ye-leucine, i-HMB-Ca ibonise ixabiso elikhethekileyo ekukhuselweni kunye nokunyangwa kwe-senile muscle decay syndrome (sarcopenia). Idatha yeklinikhi ibonisa ukuba abantu abadala abaneminyaka engama-65 ubudala bongezelela i-3 grams ye-HMB-Ca imihla ngemihla, idibaniswe nokuqeqeshwa okuphakathi kokumelana, emva kweeveki ze-12, umlinganiselo we-muscle we-muscle we-1.2kg, amandla okubamba anyuke nge-14%, kunye nesantya sokuphucula isantya safikelela kwi-23% 34. Indlela yokusebenza kwayo ibandakanya:

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Ukusebenza kwendlela ye-MTOR : ukwanda kweprotheyini ye-muscle synthesis ye-38%.

Inkqubo ye-ubiquitin evinjiweyo ye-protease: iyancipha ukubonakaliswa kwamanqaku okuphuka kwemisipha (njenge-MuRF1) nge-41%

Ilawula ibhalansi yokuvuvukala: inciphisa amanqanaba e-pro-inflammatory factor IL-6 nge-29% kwaye iphucula ukudumba okungapheliyo.

Kwinkalo yokuchasana nokuguga, irejimeni yokungenelela ye-HMB-Ca edityaniswe ne-vitamin D3 yanciphisa izinga lokulahleka kwe-telomere nge-17% kunye nokunciphisa i-cell aging-related secretory phenotype (SASP) amanqaku angama-34%. Iziko leSizwe loPhando lwezoNyango eJapan liqhuba ulingo lwezonyango lwesigaba II se-HMB-Ca ukucothisa ukuqhubela phambili kwesifo se-Alzheimer, kwaye idatha yangaphambili ibonisa ukuphuculwa kwe-19% kumanqaku okusebenza kwengqondo.

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2.Ukwakhiwa kwenkqubo yenkxaso yesondlo seklinikhi

I-HMB-Ca ivela njengesakhamzimba esiphambili kunyango lwezifo ezinzima nezingapheliyo zokumosha:

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Ulawulo lwe-cachexia yomhlaza: Ukongezwa kwasemva kokuhlinzwa kwe-3 grams ye-HMB-Ca ene-omega-3 fatty acids kwizigulana ezinomhlaza we-colorectal kunokunciphisa ilahleko yomzimba obhityileyo nge-62% kunye nokwandisa ukunyamezela ichemotherapy ngama-38%.

Inkxaso yokulungisa ukutshisa: I-30% yezigulana ezitshisa umzimba zisebenzisa amalungiselelo okutya okungenayo aqukethe i-HMB-Ca, ixesha lokuphulukisa isilonda lifinyezwa ngeentsuku ze-5-7, kwaye izinga leprotheni liyancipha ngama-41%.

Isicelo sokuvuselela ukuphefumla : Ukusetyenziswa okudibeneyo kwe-HMB-Ca kunye ne-branchchain amino acids kwizigulane ze-COPD, kwiinyanga ze-6 kamva, umgama wokuhamba ngomzuzu we-6 unyuke ngeemitha ezingama-82, amandla emisipha yokuphefumula anyuke nge-21%

I-US FDA ivume i-HMB-Ca njenge "chiza lentandane" kunyango lwe-Duchenne muscular dystrophy, kunye nesigaba sesithathu sedatha yeklinikhi ibonise ukuba amanqaku aphezulu aphuculwe nge-28% kunye nenkqubo ye-myocardial fibrosis ilibazisekile nge-19%

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3.Ukuphumelela ekulawuleni izifo ze-metabolic

Iindlela ezintsha ze-HMB-Ca kulawulo lwe-glycolipid metabolism ziye zatyhilwa:

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I-insulin sensitivity : Kuhlobo lwe-2 yezigulane zeswekile ezongezwa nge-HMB-Ca kwiiveki ze-12, i-HOMA-IR index yehle nge-23% kunye ne-skeletal muscle intake ye-glucose inyuke ngama-37%.

Ukuhlaziywa kwe-fat metabolism : Ngokuvula indlela ye-AMPK, umxholo we-triglyceride wesibindi wehle nge-29% kunye nenqanaba le-adiponectin lonyuke nge-18%

Umgaqo we-gut microbiota : Ukuveliswa kwe-asidi ye-fatty-chain emfutshane yonyuke nge-42% kunye ne-intestinal barrier function function iphuculwe nge-31% kunye notshintsho kwi-firmicutes / Bacteroides ratio.

Kunyango lwesifo sesibindi esinamafutha, i-regimen yokungenelela ye-HMB-Ca idibene ne-silymarin yanciphisa amanqaku e-fibrosis yesibindi ngamabakala e-1.2 kwaye yandisa izinga le-ALT eliqhelekileyo kwi-68% ?57. Uphononongo lwe-RCT kubantu abane-metabolic syndrome lubonise ukuncipha kwe-19% kwi-cardiovascular event risk score (ASCVD) emva kweeveki ze-24 zokungenelela.

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I-4.Ukuveliswa kokutya kwiinjongo ezikhethekileyo zonyango

Imixube ekhethekileyo yezonyango esekwe kwi-HMB-Ca iphinda ibhale imo yesondlo sezonyango:

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Ukuvuselelwa kwangaphambili kokuhlinzwa : Kwizigulane ezinokutshintshwa ngokudibeneyo, ukongeza i-6 grams ye-HMB-Ca / imini ye-3 ngaphambi kokuhlinzwa kunokuphucula isantya sokubuyiswa kwamandla emisipha emva kokuhlinzwa ngamaxesha angama-2.3 kunye nokunciphisa ubude besibhedlele ngeentsuku ze-2.5.

Ukukhuselwa kwemitha kumhlaza : Izongezelelo zesondlo zomlomo ezine-HMB-Ca entloko nasentanyeni izigulane ze-radiotherapy zinciphise iziganeko ze-mucositis nge-41% kunye nokuphucula ukuphazamiseka kwencasa ngama-57%.

Inkxaso yesondlo somntwana osandul’ ukuzalwa : Ukongezwa kwe-HMB-Ca (50mg/kg/d) kwifomula yosana olungaphambi kwexesha lonyuse ukukhula kobunzima bomzimba nge-24% kunye ne-neurodevelopmental score nge-19%

IKomishoni yezeMpilo yeSizwe yaseTshayina ibandakanye i-HMB-Ca kwiKhathalogu yeMathiriyeli yeFomula yoKutya okuKhethekileyo kuSetyenziso lwezoNyango oluKhethekileyo, kwaye ivume isicelo sayo kwiindidi ze-6 zeemveliso, kubandakanywa ne-tumor iyonke i-formula yesondlo kunye nesifo seswekile i-formula yesondlo esipheleleyo se-8. Itekhnoloji ye-HMB-Ca eqhubekayo yokukhutshwa kwe-microsphere ephuhliswe eJapan inokunyusa izinga lokufunxa amathumbu ukuya kwi-91% kwaye icuthe ukuguquguquka koluhlu lweziyobisi lwegazi ukuya kwi-± 7%

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5.Ukwandiswa kweyeza lokubuyisela kwimidlalo

Ngaphaya kwebala lezondlo lezemidlalo, ukusetyenziswa kwe-HMB-Ca kunyango lokubuyisela kwimeko yesiqhelo kuyaqhubeka ukwanda:

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Ukuvuselelwa kokulimala kwe-nerve : Kwizigulane ezinokulimala kwentambo yomgogodla, ukudityaniswa kwe-HMB-Ca kunye nokuvuselela umbane okusebenzayo kwandisa indawo enqamlezayo yeqela eliseleyo le-muscle nge-17% kunye namanqaku e-ADL ngama-23% emva kweenyanga ze-6.

Ukubuyiselwa kotyando lwamathambo : emva kokwakhiwa kwakhona kwe-anterior cruciate ligament, ukongeza i-HMB-Ca, i-quadriceps atrophy degree yancitshiswa ngama-58%, ukubuyela kwi-3-4 kwiiveki ezidlulileyo.

Ukusetyenziswa kweyeza le-Aerospace : Oosomajukujuku kwiSikhululo seNdawo samazwe ngamazwe esongezwa nge-3 grams ye-HMB-Ca imihla ngemihla banciphisa ukulahleka kwemisipha kwi-microgravity nge-72% kunye nesantya sokulahleka kwethambo ngama-39%

Kwintsimi yokukhusela ukulimala kwezemidlalo, i-HMB-Ca preconditioning regimen yanciphisa i-peak creatine kinase nge-44% kunye nobude bokulibaziseka kwe-muscle nge-51% emva kokuzivocavoca kwe-centrifugal. Umbutho waseBrithani wezoNyango lwezeMidlalo ucebisa ukuba ukuqala inkqubo yokuncedisa i-HMB-Ca kwiiveki ezi-2 ngaphambi kokuba isiganeko esiphezulu sinokunciphisa umngcipheko wokulimala kakhulu nge-37%

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6.Umda wexesha elizayo: Indibaniselwano yeBiotechnology kunye nokuveliswa kwezinto ezintsha

Ukusetyenziswa kwezifundo ezahlukeneyo ze-HMB-Ca kuvelisa i-paradigms entsha yetekhnoloji:

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Inkqubo yokuhanjiswa kwe-Nano : Ukulungiswa okujoliswe kuyo kwe-HMB-Ca efakwe kwi-liposome kwandisa ukuqokelela kwizicubu ze-muscle ngamaxesha e-3.7 kwaye ixesha elisebenzayo liyandiswa kwiiyure ze-72.

Ukulungiswa kwebhayoloji yokwenziwa : Iindleko ze-HMB-Ca zancitshiswa nge-62%, ukucoceka kwe-HMB-CA kufikelele kwi-99.9% yebakala lonyango lweyeza.

Ungenelelo lwesondlo sedijithali : isixhobo esinxitywayo esiqhagamshelwe kwi-HMB-Ca i-smart-release patch, uhlengahlengiso oluguquguqukayo lwedosi yokukhululwa ngokwe-EMG yexesha lokwenyani

Ukuphumelela kokuhlela i-Gene kuvumela ukulawulwa kwendlela ye-HMB ye-metabolic, kunye ne-CRISPR-Cas9-mediated overexpression ye-HMB synthase ibangele ukunyuka kwe-29% yendalo yobunzima bemisipha kwimodeli ye mouse. Imveliso yokuqala yehlabathi ye-HMB-Ca iye yangena kwinqanaba lesicelo seklinikhi, kwaye i-bioavailability yayo iphindwe ngama-2.8 ngaphezulu kunohlobo lwedosi yesiko.

Ukhuseleko kunye neenkcukacha zokusetyenziswa

Nangona i-HMB-Ca ibonisa amathuba osetyenziso olubanzi, kuseyimfuneko ukuqaphela:

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Ukulawulwa kwethamo: ukusetyenziswa kwexesha elide kucetyiswa ukuba kungadluli i-5 g / ngosuku, ukugqithisa kunokubangela ukuphazamiseka kwesisu.

Ukongezwa kwexesha: Kucetyiswa ukuba uyithathe ngokutya amaxesha angama-2-3, kwaye incopho yexinzelelo yegazi ihambelana nexesha lokuvuselela umthambo.

Ukuchasana : Ukusetyenziswa kwedosi ephezulu ye-antioxidants kunokuphazamisa ukusebenza kwe-mTOR indlela

I-International Society of Sports Nutrition (ISSN) ecetyisiweyo irejimeni ibonisa ukuba ukuxhaswa kwe-HMB-Ca kwiiveki ze-2-3 kunika iziphumo ezifanelekileyo, kwaye umthamo wokulondoloza unokulungiswa kwi-1-2 g / ngosuku. Ngokuqokelelwa kobungqina besicelo seklinikhi, i-HMB-Ca isuka kwisongezelelo sesondlo ukuya kwizinto ezininzi ezicwangcisiweyo ezisebenzayo, kwaye umda wayo wexabiso usakhula.