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????????????? ??хан??? ??? ???????? ???????? ??? HMB Ca ??? ???????? ????? ?????

2025-07-03

1. ?????-????????????? ?????????? ??? ??????????? ????????????

HMB ????????? ???????? ???????? ??? ????? ????? ????????? ???? ? ?????-????????? ??????????? ????? ?:

?

mTOR ??????? ????????????: ?????????? ????????? S6 ??????? ??????????????? ????? ??? 38%, ??????????? ??????? ?????? ???? ??? ?????? ???? ????????? ?????? ????????????.

??????????????? ???????? ??? ????????????????: ???? ???????????? ?? ???????? ???? E3 ??????????? ?????? MuRF1 ??? 41%, ??? ???????? ??? ???????????? ??????? ???????? ???? ????? ??????????.

?????????? ???????????: ?????????? ?? LC3-II/LC3-I ????????? ?? 1:1.5 ?? ???????? ????? ????? ?????????? ?????????? ???? ?????????????? ??????????.

????????, ??? ???????? ??? ???????????? ?????

HMB ??????????? ??? ??????????? ???? ???????????-?????? ???????????????:

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?????????????? ???? ??? ???????? ????????: ???????????? ??? ???????? ???? ???????????????????????? ??? 27%, ??????????? ?? ?????????? ???? ????????? ???? ???? ??? ????? ????????.

???????? ???? ??????????: ???????? ?? ???????????? ??????? ??? ???????????????? ?????????????? ??????????? ??????? ??? ???????? ?? ???????? ??? ???????? ??????????? ??? 63%

??? ???? ??????????? ?????: ????????????? Nrf2 ????, ?? ???????? ??? ??????????? ????????? (SOD) ??? ???????? ??? 41%

III. ????????? ????? ??? ??????? ???????

1. ???? ??????????? ??????? ???

??????? ??????? ????? ????? ??????? 3 ?/???? HMB ????? ??????????? ?? ????? ????????? ??????? (CK) ??? 44% ??? ??????????? ?? ??????? ??? ????? ??????? ??? 51%.

??? 72 ??? ??? ?????????????? ????????, ??? ?? ????????? ??? Z-????? ?????????? ??? ??????? ??????? ???????? ???????? ??? 62%, ??? ?? ??????????? ???????????? ??? ??????????????? ??? ??????????? ???????? ??? 83%.

2. ???????????? ??????????? ??????????????

??? ?????????? ??????, ????? ?? ???? ???????? ??????? ???????? ??? 19% ??? ?? ????? ?????????? ???????? ????? ??????? ??? 27% 68

??? 6-????????? ?????????? ???? ???? ???????????? VO2max ??? 4.2% ??? ???????????? ???????? ???????????? ??? 13%.

4. ??????? ???????????????? ?????????

5. ???????????? ??? ???????????? ??? ????????? ???????? ????????

??? ICU ?????????? ????? ????? ???????? ????????????? ??? HMB ????? 28 ???, ??? ?? ????????????? ????? ???? ??????? 1.3 ?? ???, ??? ?? ????? ???? ??? ????????????? ???????? ??? ???????? ??? 31%

??? ?????? ????????? ????????, ??? ?? ??????? ??????????? ???? ?????? 47% ????????? ??? ?? ?????? ??????? ???? ??? ?????? 5 ??? ??????.

2. ??????????? ??? ?????? ??????????????

??? 12 ????? ??? ???????????, ??? ?? ????-????????????? ??? ?? ?????? ????? 70 ??? ??????? ??? 0.15 ?????/???????, ??? ??? ?????? ??? ?????? ??? ?????? ??? 38%.

MRI ??? ??????? ? 21% ???????????? ??? ????????????????? ??? ????????????? ??? ? 14% ???????????? ??? ??? 2 ????? ????? ???.

5. ?????????? ??????????? ?????

?????? ???????? ??????

?????????? ??????????????? ???????????? ??? ???????? ????? ??? ???????????????? ??? 3.7 ????, ??? ?? ??????????? ???? ??? ???? ???????????????? ??? ??????

??? ?????? ??????????????? ?????? ????????? EMG ???????? ?????????? ??? ???????? ?? ??????? ???????????? ?? 15 ????????.

????????? ??? ?????????? ??????????

?? ??????????? ????????? ??????????? ??? ???????? ?? 8.7 ?/? ??? ?? ??????????? ?????? ????? ?????? ??? 62%

CRISPR ??????? ???????????? ?????????? ????? ???????????? ??? 41%, ???? ????? ??? ????-??????? ???????

6. ????????? ???????????????

?????? ??????????: ???? LD50 > 5000 ??/?? ??? ????, ??? ?????? ???? ???????.

?????-?????? ????????????: ???? ????? ?????????? ??? ???? ??????? ???????? ???? 12 ????? ??? ???????????, ??? ?? ????????? ??? ????????????????????? ?????????????? ??? ??????

????? ??????????: ????? ?? ??????? ????????????? ????? ???????????? ?? ????? 3 ?/???? ??? ???????? ??????, ?? ?????????????? ????? ????? ???????? ???? ????? ????.

????. ?????????? ????????

???????????? ??????????: ?????????? ?? ?????????? ??? HMB ???? DNA ?????????? ??????? ??? ????? ???? ????

???????? ??? ?????????? ????? ????????????: ???????? ??? ?? ?????????????? ????? ??? ??HMB ???????????? ???? ?? ????????????? ??????????/??????????? ????????????.