Okokuqala, ukungenelela kwezempilo kwabantu abadala kanye nokulwa nokuguga

Njengemetabolite eyinhloko ye-leucine, i-HMB-Ca ibonise inani eliyingqayizivele ekuvimbeleni nasekwelapheni i-senile muscle decay syndrome (i-sarcopenia). Idatha yomtholampilo ibonisa ukuthi abantu asebekhulile abaneminyaka engaphezu kwengu-65 ubudala banezela amagremu angu-3 we-HMB-Ca nsuku zonke, kuhlanganiswe nokuqeqeshwa kokumelana okulinganiselwe, ngemva kwamasonto angu-12, isilinganiso sesisindo somzimba sezitho senyuke ngo-1.2kg, amandla okubamba akhuphuka ngo-14%, futhi izinga lokuthuthukisa isivinini sesinyathelo lifinyelele ku-23% 34. Indlela yokusebenza kwayo ihlanganisa:

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Ukwenziwa kusebenze kwendlela ye-mTOR : kwenyusa ukusebenza kahle kokuhlanganiswa kwamaprotheni emisipha ngo-38%.

Isistimu ye-ubiquitin protease evinjelwe : yehlise ukubonakaliswa kwezimpawu zokuphuka kwemisipha (njenge-MuRF1) ngo-41%

Ilawula ibhalansi yokuvuvukala: yehlisa amazinga e-pro-inflammatory factor IL-6 ngo-29% futhi ithuthukise ukuvuvukala okungapheli.

Emkhakheni wokulwa nokuguga, uhlobo lokungenelela lwe-HMB-Ca oluhlanganiswe novithamini D3 lwehlise izinga lokulahleka kwe-telomere ngo-17% futhi lwehlisa omaka be-secretory phenotype (SASP) abahlobene nokuguga ngamaseli ngama-34%. I-National Longevity Medical Research Center e-Japan yenza ukuhlolwa komtholampilo kwesigaba II se-HMB-Ca ukuze kwehliswe ukuqhubeka kwesifo i-Alzheimer's, futhi idatha yokuqala ibonisa ukuthuthuka okungu-19% kuzikolo zokusebenza kwengqondo .

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2.Ukwakhiwa kohlelo lokusekela ukudla okunempilo

I-HMB-Ca ivela njengesakhi esibalulekile ekwelapheni izifo ezibucayi nezingamahlalakhona zokumosha:

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Ukuphathwa kwe-cachexia yomdlavuza : Ukwengezwa kwangemuva kokuhlinzwa kwamagremu angu-3 e-HMB-Ca nama-omega-3 fatty acids ezigulini ezinomdlavuza we-colorectal kunganciphisa ukulahlekelwa kwesisindo somzimba obuthakathaka ngo-62% futhi kwandise ukubekezelela ngamakhemikhali ngama-38%.

Ukusekelwa kokulungisa ukusha : U-30% weziguli ezishile emzimbeni zisebenzisa amalungiselelo okudla okunomsoco aqukethe i-HMB-Ca, isikhathi sokuphola kwesilonda sifinyezwa ngezinsuku ezingu-5-7, futhi izinga le-protein catabolic lehla ngo-41%.

Isicelo sokuvuselela ukuphefumula kokuphefumula : Ukusetshenziswa okuhlangene kwe-HMB-Ca nama-amino acid e-branchchain ezigulini ze-COPD, ezinyangeni ezingu-6 kamuva, ibanga lokuhamba lemizuzu engu-6 lenyuke ngamamitha angu-82, amandla emisipha yokuphefumula akhuphuke ngo-21%

I-FDA yase-US igunyaze i-HMB-Ca "njengesidakamizwa sezintandane" sokwelapha i-Duchenne muscular dystrophy, futhi idatha yomtholampilo yesigaba III ibonise ukuthi amaphuzu okusebenza kwezitho ezingenhla athuthuke ngo-28% kanye nenqubo ye-myocardial fibrosis yabambezeleka ngo-19%

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3. Ukwephulwa kokulawulwa kwezifo ze-metabolic

Izindlela ezintsha ze-HMB-Ca ekulawulweni kwe-glycolipid metabolism ziye zavezwa:

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Ukuzwela kwe-insulin : Ezigulini ezinesifo sikashukela sohlobo 2 ezingezwe nge-HMB-Ca amasonto ayi-12, inkomba ye-HOMA-IR yehle ngo-23% futhi ukuthathwa kwe-glucose yemisipha yamathambo kukhuphuke ngo-37%.

ukulungiswa kabusha kwe-fat metabolism : Ngokuvula indlela ye-AMPK, okuqukethwe kwe-triglyceride yesibindi kwehle ngo-29% kanti izinga le-adiponectin lenyuke ngo-18%

Ukulawulwa kwe-gut microbiota : ukukhiqizwa kwe-fatty chain efushane kukhuphuke ngo-42% futhi umphumela wokusebenza kwesithiyo emathunjini uthuthuke ngo-31% ngezinguquko ku-firmicutes/Bacteroides ratio

Ekwelapheni isifo sesibindi esinamafutha angenatshwala, irejimeni yokungenelela ye-HMB-Ca ehlanganiswe ne-silymarin yehlise amaphuzu esibindi se-fibrosis ngamamaki angu-1.2 futhi yandisa izinga lokujwayelekile le-ALT laya ku-68% ?57. Ucwaningo lwe-RCT kubantu abane-metabolic syndrome lubonise ukuncipha kwe-19% kumaphuzu wengozi ye-cardiovascular event risk (ASCVD) ngemva kwamasonto angu-24 okungenelela.

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4.Ukuqamba okusha ngezinjongo zokwelapha ezikhethekile

Ukwakhiwa okukhethekile kwezokwelapha okususelwe ku-HMB-Ca kubhala kabusha isimo sokudla komtholampilo:

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Ukuvuselelwa kwangaphambi kokuhlinzwa : Ezigulini ezishintshwa ngokuhlanganyela, ukwengeza amagremu angu-6 we-HMB-Ca/usuku izinsuku ezingu-3 ngaphambi kokuhlinzwa kungathuthukisa ijubane lokululama kwamandla emisipha ngemva kokuhlinzwa izikhathi ezingu-2.3 futhi kufinyeze ubude bokuhlala esibhedlela ngezinsuku ezingu-2.5

Ukuvikelwa kwemisebe kumdlavuza : Isengezo sokudla okunempilo ngomlomo esiqukethe i-HMB-Ca ezigulini ze-radiotherapy ekhanda nasentanyeni sinciphise ukwenzeka kwe-mucositis ngo-41% kanye nokuphazamiseka kokunambitha okuthuthukisiwe ngama-57%

Ukwesekwa komsoco osanda kuzalwa : Ukwengezwa kwe-HMB-Ca (50mg/kg/d) kufomula yezingane ezisanda kuzalwa kukhuphule ukukhula kwesisindo somzimba ngo-24% kanye ne-neurodevelopmental score ngo-19%

Ikhomishana Kazwelonke Yezempilo YaseChina ifake i-HMB-Ca Ohlwini Lwezinto Ezingavuthiwe Zokudla Kwefomula Yokusetshenziswa Okukhethekile Kwezokwelapha, futhi yagunyaza ukusetshenziswa kwayo ezigabeni eziyisi-6 zemikhiqizo, okuhlanganisa nefomula yefomula yokudla okuphelele kwesimila kanye nefomula ephelele yokudla okunempilo kwesifo sikashukela esingu-8. Ubuchwepheshe be-HMB-Ca obuhlala njalo bokukhishwa kwe-microsphere obuthuthukiswe e-Japan bunganyusa izinga lokumuncwa kwamathumbu bufinyelele ku-91% futhi bunciphise uhla lokuguquguquka lokugxiliswa kwezidakamizwa egazini lube ku-±7%

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5.Ukunwetshwa komuthi wokuvuselela ezemidlalo

Ngale kwenkambu yendabuko yokudla kwezemidlalo, ukusetshenziswa kwe-HMB-Ca emithini yokuvuselela kuyaqhubeka nokukhula:

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Ukuvuselelwa kokulimala kwenzwa : Ezigulini ezinokulimala komgogodla, inhlanganisela ye-HMB-Ca kanye nokuvuselela kagesi okusebenzayo kukhulise indawo ye-cross-sectional yeqembu elisele lemisipha ngo-17% kanye nesikolo se-ADL ngama-23% ngemva kwezinyanga ezingu-6.

Ukuvuselelwa kokuhlinzwa kwamathambo : ngemuva kokwakhiwa kabusha kwe-anterior cruciate ligament, ukwengeza i-HMB-Ca, i-quadriceps atrophy degree yehliswe ngo-58%, ukubuya kokuzivocavoca emavikini angu-3-4 ngaphambili

Izinhlelo zokusebenza zemithi ye-Aerospace : Osomkhathi eSiteshini Somkhathi Samazwe Ngamazwe abengezwe ngamagremu angu-3 e-HMB-Ca nsuku zonke banciphise ukulahlekelwa kwemisipha ku-microgravity ngo-72% kanye nezinga lokulahlekelwa ukuminyana kwamathambo ngo-39%

Emkhakheni wokuvikela ukulimala kwezemidlalo, i-HMB-Ca preconditioning regimen yehlise inani eliphakeme le-creatine kinase ngo-44% kanye nobude bokubambezeleka kobuhlungu bemisipha ngo-51% ngemva kokuzivocavoca kwe-centrifugal . I-British Association of Sports Medicine incoma ukuthi ukuqala uhlelo lokungezelela lwe-HMB-Ca amasonto angu-2 ngaphambi komcimbi onzima kakhulu kunganciphisa ingozi yokulimala kanzima ngo-37%

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6.Umngcele wesikhathi esizayo: Ukuhlanganiswa kwe-Biotechnology kanye nokusungula izinto ezintsha

Ukusetshenziswa kwezinhlaka ezahlukene kwe-HMB-Ca kuveza ama-paradigms obuchwepheshe obusha:

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Uhlelo lokulethwa kwe-Nano : Ukulungiswa okuhlosiwe kwe-HMB-Ca efakwe ku-liposome kwandisa ukuqoqwa kwezicubu zemisipha izikhathi ezingu-3.7 futhi isikhathi esisebenzayo sinwetshwa emahoreni angu-72

Ukulungiswa kwebhayoloji yokwenziwa : Izindleko ze-HMB-Ca zehliswe ngo-62%, ubumsulwa be-HMB-CA bufinyelele ku-99.9% izinga lebanga lezemithi

Ukungenelela okunomsoco wedijithali : idivayisi egqokekayo exhunywe isiqeshana sokukhishwa okuqinile kwe-HMB-Ca, lungisa ngamandla umthamo wokukhishwa ngokuya nge-EMG yesikhathi sangempela

Ukuphumelela kokuhlela i-Gene kunika amandla ukulawulwa kwendlela ye-HMB ye-metabolic, futhi i-CRISPR-Cas9-mediated overexpression ye-HMB synthase ibangele ukwanda okungokwemvelo kwama-29% kumodeli yegundane. Ukulungiswa komkhiqizo wokuqala emhlabeni we-HMB-Ca sekungene esigabeni sokusetshenziswa komtholampilo, futhi i-bioavailability yayo iphakeme ngokuphindwe izikhathi ezingu-2.8 kunaleyo yamafomu emithamo evamile.

Ukuphepha nokucaciswa kohlelo lokusebenza

Nakuba i-HMB-Ca ibonisa amathemba ohlelo olubanzi, kusadingeka ukuqaphela:

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Ukulawulwa komthamo: ukusetshenziswa isikhathi eside kunconywa ukuthi kungadluli ku-5 g / ngosuku, ukweqisa kungadala ukungakhululeki emathunjini.

Ukulungiselela isikhathi : Kunconywa ukuthi uyiphuze kanye nokudla izikhathi ezi-2-3, futhi inani eliphakeme legazi lihambisana nesikhathi sokuvuselela umzimba.

Ukuphikisana : Ukuthatha imithamo ephezulu yama-antioxidants kungase kukhinyabeze ukusebenza kwe-mTOR pathway

Uhlelo olunconyiwe lwe-International Society of Sports Nutrition (ISSN) lubonisa ukuthi ukwengezwa kwe-HMB-Ca amaviki angu-2-3 kunikeza imiphumela emihle, futhi umthamo wokunakekela ungalungiswa ube ngu-1-2 g/ngosuku . Ngokuqoqwa kobufakazi bokusebenza komtholampilo, i-HMB-Ca iyashintsha isuka ekubeni yizithasiselo zokudla okunomsoco iye entweni yokusebenza yamasu ehlukene, futhi umkhawulo wenani layo usakhula .